Ferroptosis resistance mediated by exosomal release of iron

Abstract

Understanding how cells resist ferroptosis is necessary for exploiting this iron-dependent mode of cell death for the treatment of cancer and other diseases. We discovered that cells resist ferroptosis by enabling a PROMININ2-dependent iron export pathway involving multivesicular body/exosome trafficking of iron out of the cell, diminishing the intracellular iron needed for ferroptosis.

Keywords

• ferroptosis
• prominin2
• iron
• multivesicular body
• exosome
• breast cancer
• therapy
• gpx4