PLoS ONE (Jan 2013)

Association analysis of genetic variants in the myosin IXB gene in acute pancreatitis.

  • Rian M Nijmeijer,
  • Hjalmar C van Santvoort,
  • Alexandra Zhernakova,
  • Steffen Teller,
  • Jonas A Scheiber,
  • Carolien G de Kovel,
  • Marc G H Besselink,
  • Jeroen T J Visser,
  • Femke Lutgendorff,
  • Thomas L Bollen,
  • Marja A Boermeester,
  • Ger T Rijkers,
  • Frank U Weiss,
  • Julia Mayerle,
  • Markus M Lerch,
  • Hein G Gooszen,
  • Louis M A Akkermans,
  • Cisca Wijmenga,
  • Dutch Pancreatitis Study Group

DOI
https://doi.org/10.1371/journal.pone.0085870
Journal volume & issue
Vol. 8, no. 12
p. e85870

Abstract

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IntroductionImpairment of the mucosal barrier plays an important role in the pathophysiology of acute pancreatitis. The myosin IXB (MYO9B) gene and the two tight-junction adaptor genes, PARD3 and MAGI2, have been linked to gastrointestinal permeability. Common variants of these genes are associated with celiac disease and inflammatory bowel disease, two other conditions in which intestinal permeability plays a role. We investigated genetic variation in MYO9B, PARD3 and MAGI2 for association with acute pancreatitis.MethodsFive single nucleotide polymorphisms (SNPs) in MYO9B, two SNPs in PARD3, and three SNPs in MAGI2 were studied in a Dutch cohort of 387 patients with acute pancreatitis and over 800 controls, and in a German cohort of 235 patients and 250 controls.ResultsAssociation to MYO9B and PARD3 was observed in the Dutch cohort, but only one SNP in MYO9B and one in MAGI2 showed association in the German cohort (p ConclusionVariants in MYO9B may be involved in acute pancreatitis, but we found no evidence for involvement of PARD3 or MAGI2.