Nature Communications (Nov 2021)

Fast alignment and preprocessing of chromatin profiles with Chromap

  • Haowen Zhang,
  • Li Song,
  • Xiaotao Wang,
  • Haoyu Cheng,
  • Chenfei Wang,
  • Clifford A. Meyer,
  • Tao Liu,
  • Ming Tang,
  • Srinivas Aluru,
  • Feng Yue,
  • X. Shirley Liu,
  • Heng Li

DOI
https://doi.org/10.1038/s41467-021-26865-w
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 6

Abstract

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As studies continue sequencing with deeper coverage, computational processing of these profiles has become increasingly resource consuming. Here the authors designed an efficient computational method called Chromap to align and preprocess high throughput sequencing data from chromatin profiling techniques, including ChIP-seq, Hi-C, or scATAC-seq, with a major decrease in runtime.