Parameters estimation for amino acids adsorption in a fixed bed by moment analysis

Brazilian Journal of Chemical Engineering. 2001;18(2):181-194 DOI 10.1590/S0104-66322001000200006


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Journal Title: Brazilian Journal of Chemical Engineering

ISSN: 0104-6632 (Print); 1678-4383 (Online)

Publisher: Brazilian Society of Chemical Engineering

LCC Subject Category: Technology: Chemical technology: Chemical engineering

Country of publisher: Brazil

Language of fulltext: English

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M.A. Cremasco
B.J. Hritzko
Yi Xie
N.H. L. Wang


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Time From Submission to Publication: 12 weeks


Abstract | Full Text

Equilibrium constant and mass transfer parameters are needed for the study of amino acid separation in any process involving adsorption in fixed beds. The adsorption constants, effective diffusion coefficients, and axial dispersion coefficients for two amino acids, L-phenylalanine (Phe) and L-tyrosine (Tyr), are determined from a series of pulse tests in a fixed bed packed with PVP (poly-4-vinylpyridine) resin. Total bed voidage at different flow rates is estimated from NaCl pulse test data. The effective pore diffusivities of Phe, Tyr, and NaCl are estimated from moment analysis of pulse data. A detailed rate model is then solved numerically and adsorption constants, effective diffusion coefficients, axial dispersion coefficients are determined by moment analysis and compared with the pulse data. The advantage of this method is that the effective intraparticle diffusivities can be determined without the influence of extracolumn dispersion or intracolumn axial dispersion effects.