eNeurologicalSci (Mar 2021)
Posterior reversible encephalopathy syndrome and COVID-19: A series of 6 cases from Lombardy, Italy
- Antonio Colombo,
- Filippo Martinelli Boneschi,
- Sandro Beretta,
- Nereo Bresolin,
- Maurizio Versino,
- Lorenzo Lorusso,
- Diego Spagnoli,
- Giulia Nastasi,
- Davide Vallauri,
- Stefania Rota,
- Maria Repaci,
- Massimo Ferrarini,
- Mattia Pozzato,
- Lucia Princiotta Cariddi,
- Payam Tabaee Damavandi,
- Federico Carimati,
- Paola Banfi,
- Alessandro Clemenzi,
- Margherita Marelli,
- Andrea Giorgianni,
- Gabriele Vinacci,
- Marco Mauri,
- Paola Melzi,
- Maria Di Stefano,
- Antonio Tetto,
- Margherita Canesi,
- Andrea Salmaggi
Affiliations
- Antonio Colombo
- SNO (Society of Hospital Neurosciences, Italy) and Polo Neurologico Brianteo, Seregno, MB, Italy
- Filippo Martinelli Boneschi
- Dino Ferrari Centre, Department of Pathophysiology and Transplantation (DEPT), University of Milan and IRCCS Ca' Granda Foundation Ospedale Maggiore Policlinico, Neurology Unit and MS Center Milan, Italy
- Sandro Beretta
- Neurology and Stroke Unit, Radiology Unity, ASST Vimercate (MB), Italy
- Nereo Bresolin
- Dino Ferrari Centre, Department of Pathophysiology and Transplantation (DEPT), University of Milan and IRCCS Ca' Granda Foundation Ospedale Maggiore Policlinico, Neurology Unit and MS Center Milan, Italy
- Maurizio Versino
- University of Insubria, Clinical and Experimental Medicine and Medical Humanitates, Center of Research in Medical Pharmacology, Neurology and Stroke Unit, Neuroradiology, Pneumology ASST Sette Laghi, Varese, Italy
- Lorenzo Lorusso
- Neurology and Stroke Unit Merate Hospital, ASST, Lecco, Italy
- Diego Spagnoli
- Neurosurgery and Neurorehabilitation Gravedona Hospital, Como, Italy
- Giulia Nastasi
- Neurology and Stroke Unit, Radiology Unity, ASST Vimercate (MB), Italy
- Davide Vallauri
- Neurology and Stroke Unit, Radiology Unity, ASST Vimercate (MB), Italy
- Stefania Rota
- Neurology and Stroke Unit, Radiology Unity, ASST Vimercate (MB), Italy
- Maria Repaci
- Neurology and Stroke Unit, Radiology Unity, ASST Vimercate (MB), Italy
- Massimo Ferrarini
- Neurology and Stroke Unit, Radiology Unity, ASST Vimercate (MB), Italy
- Mattia Pozzato
- Dino Ferrari Centre, Department of Pathophysiology and Transplantation (DEPT), University of Milan and IRCCS Ca' Granda Foundation Ospedale Maggiore Policlinico, Neurology Unit and MS Center Milan, Italy
- Lucia Princiotta Cariddi
- University of Insubria, Clinical and Experimental Medicine and Medical Humanitates, Center of Research in Medical Pharmacology, Neurology and Stroke Unit, Neuroradiology, Pneumology ASST Sette Laghi, Varese, Italy
- Payam Tabaee Damavandi
- University of Insubria, Clinical and Experimental Medicine and Medical Humanitates, Center of Research in Medical Pharmacology, Neurology and Stroke Unit, Neuroradiology, Pneumology ASST Sette Laghi, Varese, Italy
- Federico Carimati
- University of Insubria, Clinical and Experimental Medicine and Medical Humanitates, Center of Research in Medical Pharmacology, Neurology and Stroke Unit, Neuroradiology, Pneumology ASST Sette Laghi, Varese, Italy
- Paola Banfi
- University of Insubria, Clinical and Experimental Medicine and Medical Humanitates, Center of Research in Medical Pharmacology, Neurology and Stroke Unit, Neuroradiology, Pneumology ASST Sette Laghi, Varese, Italy
- Alessandro Clemenzi
- University of Insubria, Clinical and Experimental Medicine and Medical Humanitates, Center of Research in Medical Pharmacology, Neurology and Stroke Unit, Neuroradiology, Pneumology ASST Sette Laghi, Varese, Italy
- Margherita Marelli
- University of Insubria, Clinical and Experimental Medicine and Medical Humanitates, Center of Research in Medical Pharmacology, Neurology and Stroke Unit, Neuroradiology, Pneumology ASST Sette Laghi, Varese, Italy
- Andrea Giorgianni
- University of Insubria, Clinical and Experimental Medicine and Medical Humanitates, Center of Research in Medical Pharmacology, Neurology and Stroke Unit, Neuroradiology, Pneumology ASST Sette Laghi, Varese, Italy
- Gabriele Vinacci
- University of Insubria, Clinical and Experimental Medicine and Medical Humanitates, Center of Research in Medical Pharmacology, Neurology and Stroke Unit, Neuroradiology, Pneumology ASST Sette Laghi, Varese, Italy
- Marco Mauri
- University of Insubria, Clinical and Experimental Medicine and Medical Humanitates, Center of Research in Medical Pharmacology, Neurology and Stroke Unit, Neuroradiology, Pneumology ASST Sette Laghi, Varese, Italy
- Paola Melzi
- Neurology and Stroke Unit Merate Hospital, ASST, Lecco, Italy
- Maria Di Stefano
- Neurology and Stroke Unit Merate Hospital, ASST, Lecco, Italy
- Antonio Tetto
- Neurology and Stroke Unit Merate Hospital, ASST, Lecco, Italy
- Margherita Canesi
- Neurosurgery and Neurorehabilitation Gravedona Hospital, Como, Italy
- Andrea Salmaggi
- Neurology and Stroke Unit ASST, Lecco, Italy; Corresponding author.
- Journal volume & issue
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Vol. 22
p. 100306
Abstract
Posterior reversible encephalopathy cases are increasingly being reported in patients affected by COVID-19, but the largest series so far only includes 4 patients. We present a series of 6 patients diagnosed with PRES during COVID-19 hospitalized in 5 Centers in Lombardia, Italy. 5 out of the 6 patients required intensive care assistence and seizures developed at weaning from assisted ventilation. 3 out of 6 patients underwent cerebrospinal fluid analysis which was normal in all cases, with negative PCR for Sars-CoV-2 genome search. PRES occurrence may be less rare than supposed in COVID-19 patients and a high suspicion index is warranted for prompt diagnosis and treatment.
