Current Oncology (Mar 2024)
Successful Multimodal Treatment of Intracranial Growing Teratoma Syndrome with Malignant Features
- Daiken Satake,
- Manabu Natsumeda,
- Kaishi Satomi,
- Mari Tada,
- Taro Sato,
- Noritaka Okubo,
- Keita Kawabe,
- Haruhiko Takahashi,
- Yoshihiro Tsukamoto,
- Masayasu Okada,
- Masakazu Sano,
- Haruko Iwabuchi,
- Nao Shibata,
- Masaru Imamura,
- Chihaya Imai,
- Hirokazu Takami,
- Koichi Ichimura,
- Ryo Nishikawa,
- Hajime Umezu,
- Akiyoshi Kakita,
- Makoto Oishi
Affiliations
- Daiken Satake
- Department of Neurosurgery, Brain Research Institute, Niigata University, Niigata 951-8585, Japan
- Manabu Natsumeda
- Department of Neurosurgery, Brain Research Institute, Niigata University, Niigata 951-8585, Japan
- Kaishi Satomi
- Department of Pathology, Kyorin University Faculty of Medicine, Tokyo 181-8611, Japan
- Mari Tada
- Department of Pathology, Brain Research Institute, Niigata University, Niigata 951-8585, Japan
- Taro Sato
- Department of Neurosurgery, Brain Research Institute, Niigata University, Niigata 951-8585, Japan
- Noritaka Okubo
- Department of Neurosurgery, Brain Research Institute, Niigata University, Niigata 951-8585, Japan
- Keita Kawabe
- Department of Neurosurgery, Brain Research Institute, Niigata University, Niigata 951-8585, Japan
- Haruhiko Takahashi
- Department of Neurosurgery, Brain Research Institute, Niigata University, Niigata 951-8585, Japan
- Yoshihiro Tsukamoto
- Department of Neurosurgery, Brain Research Institute, Niigata University, Niigata 951-8585, Japan
- Masayasu Okada
- Department of Neurosurgery, Brain Research Institute, Niigata University, Niigata 951-8585, Japan
- Masakazu Sano
- Department of Neurosurgery, Brain Research Institute, Niigata University, Niigata 951-8585, Japan
- Haruko Iwabuchi
- Department of Pediatrics, Niigata University Medical and Dental Hospital, Niigata 951-8520, Japan
- Nao Shibata
- Department of Pediatrics, Niigata University Medical and Dental Hospital, Niigata 951-8520, Japan
- Masaru Imamura
- Department of Pediatrics, Niigata University Medical and Dental Hospital, Niigata 951-8520, Japan
- Chihaya Imai
- Department of Pediatrics, Niigata University Medical and Dental Hospital, Niigata 951-8520, Japan
- Hirokazu Takami
- Department of Neurosurgery, The University of Tokyo Hospital, Tokyo 113-8655, Japan
- Koichi Ichimura
- Department of Brain Disease Translational Research, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan
- Ryo Nishikawa
- Department of Neurosurgery/Neuro-Oncology, Saitama Medical University International Medical Center, Saitama 350-1298, Japan
- Hajime Umezu
- Division of Pathology, Niigata University Medical and Dental Hospital, Niigata University, Niigata 951-8520, Japan
- Akiyoshi Kakita
- Department of Pathology, Brain Research Institute, Niigata University, Niigata 951-8585, Japan
- Makoto Oishi
- Department of Neurosurgery, Brain Research Institute, Niigata University, Niigata 951-8585, Japan
- DOI
- https://doi.org/10.3390/curroncol31040138
- Journal volume & issue
-
Vol. 31,
no. 4
pp. 1831 – 1838
Abstract
Molecular analysis of the growing teratoma syndrome has not been extensively studied. Here, we report a 14-year-old boy with a growing mass during treatment for a mixed germ cell tumor of the pineal region. Tumor markers were negative; thus, growing teratoma syndrome was suspected. A radical resection via the occipital transtentorial approach was performed, and histopathological examination revealed a teratoma with malignant features. Methylation classifier analysis confirmed the diagnosis of teratoma, and DMRT1 loss and 12p gain were identified by copy number variation analysis, potentially elucidating the cause of growth and malignant transformation of the teratoma. The patient remains in remission after intense chemoradiation treatment as a high-risk germ cell tumor.
Keywords
- growing teratoma syndrome
- multimodal treatment
- methylation classifier
- copy number variation analysis
