Nature Communications (Jun 2017)
Zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus
- Petraleigh Pantoja,
- Erick X. Pérez-Guzmán,
- Idia V. Rodríguez,
- Laura J. White,
- Olga González,
- Crisanta Serrano,
- Luis Giavedoni,
- Vida Hodara,
- Lorna Cruz,
- Teresa Arana,
- Melween I. Martínez,
- Mariah A. Hassert,
- James D. Brien,
- Amelia K. Pinto,
- Aravinda de Silva,
- Carlos A. Sariol
Affiliations
- Petraleigh Pantoja
- Unit of Comparative Medicine, Caribbean Primate Research Center, University of Puerto Rico-Medical Sciences Campus
- Erick X. Pérez-Guzmán
- Department of Microbiology and Medical Zoology, University of Puerto Rico-Medical Sciences Campus
- Idia V. Rodríguez
- Unit of Comparative Medicine, Caribbean Primate Research Center, University of Puerto Rico-Medical Sciences Campus
- Laura J. White
- Department of Microbiology and Immunology, University of North Carolina-Chapel Hill
- Olga González
- Unit of Comparative Medicine, Caribbean Primate Research Center, University of Puerto Rico-Medical Sciences Campus
- Crisanta Serrano
- Department of Microbiology and Medical Zoology, University of Puerto Rico-Medical Sciences Campus
- Luis Giavedoni
- Texas Biomedical Research Institute
- Vida Hodara
- Texas Biomedical Research Institute
- Lorna Cruz
- Unit of Comparative Medicine, Caribbean Primate Research Center, University of Puerto Rico-Medical Sciences Campus
- Teresa Arana
- Department of Microbiology and Medical Zoology, University of Puerto Rico-Medical Sciences Campus
- Melween I. Martínez
- Unit of Comparative Medicine, Caribbean Primate Research Center, University of Puerto Rico-Medical Sciences Campus
- Mariah A. Hassert
- Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine
- James D. Brien
- Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine
- Amelia K. Pinto
- Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine
- Aravinda de Silva
- Department of Microbiology and Immunology, University of North Carolina-Chapel Hill
- Carlos A. Sariol
- Unit of Comparative Medicine, Caribbean Primate Research Center, University of Puerto Rico-Medical Sciences Campus
- DOI
- https://doi.org/10.1038/ncomms15674
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
Antibodies against dengue virus (DENV) can increase Zika virus (ZIKV) infectionin vitro, but their role in vivoremains largely unknown. Here, the authors show that pre-existing immunity from a 2.8 years earlier DENV infection does not affect ZIKV pathogenesis in macaques but instead shortens Zika viremia.
