Spirostrain-Accelerated Chemiexcitation of Dioxetanes Yields Unprecedented Detection Sensitivity in Chemiluminescence Bioassays

• Rozan Tannous,
• Omri Shelef,
• Sara Gutkin,
• Maya David,
• Thomas Leirikh,
• Liang Ge,
• Qais Jaber,
• Qingyang Zhou,
• Pengchen Ma,
• Micha Fridman,
• Urs Spitz,
• Kendall N. Houk,
• Doron Shabat

Affiliations

Rozan Tannous

School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel-Aviv University, Tel Aviv, Israel

Omri Shelef

School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel-Aviv University, Tel Aviv, Israel

Sara Gutkin

School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel-Aviv University, Tel Aviv, Israel

Maya David

School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel-Aviv University, Tel Aviv, Israel

Thomas Leirikh

School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel-Aviv University, Tel Aviv, Israel

Liang Ge

School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel-Aviv University, Tel Aviv, Israel

Qais Jaber

School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel-Aviv University, Tel Aviv, Israel

Qingyang Zhou

Department of Chemistry and Biochemistry, University of California, Los Angeles, California, United States

Pengchen Ma

Department of Chemistry and Biochemistry, University of California, Los Angeles, California, United States

Micha Fridman

School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel-Aviv University, Tel Aviv, Israel

Urs Spitz

BIOSYNTH, Staad, Switzerland

Kendall N. Houk

Department of Chemistry and Biochemistry, University of California, Los Angeles, California, United States

Doron Shabat

School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel-Aviv University, Tel Aviv, Israel