Inflammatory Markers Used as Predictors of Subclinical Atherosclerosis in Patients with Diabetic Polyneuropathy
Adrian Vasile Mureșan,
Alexandru Tomac,
Diana Roxana Opriș,
Bogdan Corneliu Bandici,
Cătălin Mircea Coșarcă,
Diana Carina Covalcic,
Ioana Hălmaciu,
Orsolya-Zsuzsa Akácsos-Szász,
Flavia Rădulescu,
Krisztina Lázár,
Adina Stoian,
Mariana Cornelia Tilinca
Affiliations
Adrian Vasile Mureșan
Clinic of Vascular Surgery, Mures County Emergency Hospital, 540136 Targu Mures, Romania
Alexandru Tomac
Clinic of Plastic Surgery, Emergency Clinical Hospital Saint Spiridon, 700111 Iasi, Romania
Diana Roxana Opriș
Emergency Institute for Cardiovascular Diseases and Transplantation (IUBCVT) of Targu Mures, 540136 Targu Mures, Romania
Bogdan Corneliu Bandici
Clinic of Vascular Surgery, Mures County Emergency Hospital, 540136 Targu Mures, Romania
Cătălin Mircea Coșarcă
Clinic of Vascular Surgery, Mures County Emergency Hospital, 540136 Targu Mures, Romania
Diana Carina Covalcic
Clinic of Vascular Surgery, Mures County Emergency Hospital, 540136 Targu Mures, Romania
Ioana Hălmaciu
Department of Radiology, Mures County Emergency Hospital, 540136 Targu Mures, Romania
Orsolya-Zsuzsa Akácsos-Szász
Doctoral School of Medicine and Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania
Flavia Rădulescu
Clinical Department of Endocrinology, Mures County Emergency Hospital, 540136 Targu Mures, Romania
Krisztina Lázár
Clinical Department of Endocrinology, Mures County Emergency Hospital, 540136 Targu Mures, Romania
Adina Stoian
Department of Pathophysiology, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540139 Targu Mures, Romania
Mariana Cornelia Tilinca
Department of Diabetes, Nutrition and Metabolic Diseases, Mures County Emergency Hospital, 540136 Targu Mures, Romania
Background: peripheral arterial disease (PAD) is identified late in diabetic patients because, in the majority of cases, it is associated with diabetic peripheral neuropathy, resulting in little or no symptoms, or symptoms that are completely neglected. Methods: In this study were enrolled all patients over 18 years of age, with diabetes mellitus type II for more than a year with poor glycemic control, diagnosed with diabetic polyneuropathy admitted to the Diabetology Department, Emergency County Hospital of Targu Mures, Romania between January 2020 and March 2023. We divided the patients into two groups, based on the presence or absence of subclinical atherosclerosis in the lower limb, named “SA” and “non-SA”. Results: Patients in the SA group were older (p = 0.01) and had a higher incidence of IHD (p = 0.03), history of MI (p = 0.02), and diabetic nephropathy (p = 0.01). Moreover, patients with subclinical atherosclerosis had a higher BMI (p p p p p p p p p p = 0.006), a higher baseline levels of BMI (OR: 7.71, p p p p p < 0.001 for admission glucose) are independent predictors of SA. Conclusions: the inflammatory markers, NLR, MLR, PLR, and SII, being cheap and easy to collect in routine medical practice from the standard blood tests, could be an important step in predicting vascular outcomes in diabetic patients and the disease’s progression, playing a key role in follow-up visits in type-2 diabetic patients and PAD patients.
