The analgesic effect of Curcuma Longa rhizome methanol extract in male rat

Abstract

Background: There are several reports on the therapeutic effects of curcuma longa in traditional medicine such as anti inflammatory, antinocieptive , antioxidant ,anti carcinogenic and hepatoprotective effects. Therefore, In this study we investigated the the analgesic effect of this Plant in experimental models of acute and chronic Pain as compare to Sodium Salicylate. Methods: Curcuma Longa extract were prepared using percolation method. Different dose of root extract (100/200/300 mg/ kg i. p ) and sodium salicylate (300 mg/kg i. P) were given. The analgesic activity was assessed in experimental models of acute pain (tail flick) and chronic pain (used formalin test). Findings: All dose of extract and sodium salicylate had analgesic effect than control group in tail flick test& second of phase formalin test (P<0.05). Conclusion: It seems that Curcuma Longa induces its inhibitory effect on acute and chronic Pain.

Keywords

• curcuma longa extract- pain- sodium salicylate