Nature Communications (Jul 2019)
Synthetic modeling reveals HOXB genes are critical for the initiation and maintenance of human leukemia
- Manabu Kusakabe,
- Ann Chong Sun,
- Kateryna Tyshchenko,
- Rachel Wong,
- Aastha Nanda,
- Claire Shanna,
- Samuel Gusscott,
- Elizabeth A. Chavez,
- Alireza Lorzadeh,
- Alice Zhu,
- Ainsleigh Hill,
- Stacy Hung,
- Scott Brown,
- Artem Babaian,
- Xuehai Wang,
- Robert A. Holt,
- Christian Steidl,
- Aly Karsan,
- R. Keith Humphries,
- Connie J. Eaves,
- Martin Hirst,
- Andrew P. Weng
Affiliations
- Manabu Kusakabe
- Terry Fox Laboratory, BC Cancer Agency
- Ann Chong Sun
- Terry Fox Laboratory, BC Cancer Agency
- Kateryna Tyshchenko
- Terry Fox Laboratory, BC Cancer Agency
- Rachel Wong
- Terry Fox Laboratory, BC Cancer Agency
- Aastha Nanda
- Terry Fox Laboratory, BC Cancer Agency
- Claire Shanna
- Terry Fox Laboratory, BC Cancer Agency
- Samuel Gusscott
- Terry Fox Laboratory, BC Cancer Agency
- Elizabeth A. Chavez
- Lymphoid Cancer Research, BC Cancer Agency
- Alireza Lorzadeh
- Department of Microbiology and Immunology, Michael Smith Laboratories, University of British Columbia
- Alice Zhu
- Department of Microbiology and Immunology, Michael Smith Laboratories, University of British Columbia
- Ainsleigh Hill
- Terry Fox Laboratory, BC Cancer Agency
- Stacy Hung
- Lymphoid Cancer Research, BC Cancer Agency
- Scott Brown
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
- Artem Babaian
- Terry Fox Laboratory, BC Cancer Agency
- Xuehai Wang
- Terry Fox Laboratory, BC Cancer Agency
- Robert A. Holt
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
- Christian Steidl
- Lymphoid Cancer Research, BC Cancer Agency
- Aly Karsan
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
- R. Keith Humphries
- Terry Fox Laboratory, BC Cancer Agency
- Connie J. Eaves
- Terry Fox Laboratory, BC Cancer Agency
- Martin Hirst
- Department of Microbiology and Immunology, Michael Smith Laboratories, University of British Columbia
- Andrew P. Weng
- Terry Fox Laboratory, BC Cancer Agency
- DOI
- https://doi.org/10.1038/s41467-019-10510-8
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
Studies with patient derived xenografts are hampered by factors such as genetic variability and sample availability. Here, the authors generate a leukemia mouse model by lentiviral transduction of normal human cord blood and show an oncogenic role of HOXB genes.
