Nature Communications (Sep 2020)

Broadly neutralizing plasma antibodies effective against autologous circulating viruses in infants with multivariant HIV-1 infection

  • Nitesh Mishra,
  • Shaifali Sharma,
  • Ayushman Dobhal,
  • Sanjeev Kumar,
  • Himanshi Chawla,
  • Ravinder Singh,
  • Muzamil Ashraf Makhdoomi,
  • Bimal Kumar Das,
  • Rakesh Lodha,
  • Sushil Kumar Kabra,
  • Kalpana Luthra

DOI
https://doi.org/10.1038/s41467-020-18225-x
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 11

Abstract

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Some infants develop broadly neutralizing antibodies (bnAbs) to HIV in a shorter time frame than adults, but the reasons aren’t well understood. Here, the authors study a cohort of 51 HIV-1 clade C perinatally infected infants of Indian origin and find that multivariant infection is associated with bnAbs in elite neutralizers.