Cancer Management and Research (Nov 2020)

Predictive Value of Some Inflammatory Indexes in the Survival and Toxicity of Nasopharyngeal Carcinoma

  • Han YY,
  • Chen KH,
  • Guan Y,
  • Chen L,
  • Lin MR,
  • Nong SK,
  • Zhu XD

Journal volume & issue
Vol. Volume 12
pp. 11541 – 11551

Abstract

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Yu-Yuan Han,1,2 Kai-Hua Chen,1,2 Ying Guan,1 Li Chen,1,2 Man-Ru Lin,1 Si-Kai Nong,3 Xiao-Dong Zhu1– 3 1Department of Radiation Oncology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi 530021, People’s Republic of China; 2Guangxi Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor, Guangxi Medical University, Nanning, Guangxi 530021, People’s Republic of China; 3Department of Oncology, Wuming Hospital of Guangxi Medical University, Nanning, Guangxi 530199, People’s Republic of ChinaCorrespondence: Xiao-Dong ZhuDepartment of Radiation Oncology, Guangxi Medical University Cancer Hospital, 71 He Di Road, Nanning 530021, People’s Republic of ChinaTel +86 771 533 1466Email [email protected]: The present study aimed to investigate the predictive value of some inflammatory indexes, such as the ratio of C-reactive protein-to-albumin (CAR), high-sensitivity C-reactive protein-to-albumin (HCAR), C-reactive protein-to-lymphocyte (CLR), and high-sensitivity C-reactive protein-to-lymphocyte (HCLR) in the survival and toxicity of nasopharyngeal carcinoma and provide reference for the development of treatment.Methods: A retrospective analysis was conducted on 162 patients from 2013 to 2018. The value of the indexes before the treatment was calculated. SPSS 25.0 software was used for the analysis, and the cutoff values of the indexes were determined by the receiver operating characteristic curve (ROC). The prognostic value of the indexes was evaluated according to the overall survival rate (OS), progression-free survival rate (PFS), and the incidence of toxic side effects.Results: The index CLR was found to be the predictor of mortality of nasopharyngeal carcinoma but not the indicator for toxicity.Conclusion: The index CLR can be used for risk-stratification. However, whether the risk-stratification treatment based on these indicators can improve the prognosis subsequently needs further prospective study.Keywords: nasopharyngeal carcinoma, C-reactive protein/albumin ratio, high-sensitivity C-reactive protein/albumin ratio, C-reactive protein/lymphocyte ratio, high-sensitivity C-reactive protein/lymphocyte ratio, survival, toxicity

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