Advancements in genetic research by the Hispanic Community Health Study/Study of Latinos: A 10-year retrospective review
Hridya Rao,
Margaret C. Weiss,
Jee Young Moon,
Krista M. Perreira,
Martha L. Daviglus,
Robert Kaplan,
Kari E. North,
Maria Argos,
Lindsay Fernández-Rhodes,
Tamar Sofer
Affiliations
Hridya Rao
Department of Biobehavioral Health, Pennsylvania State University, University Park, PA, USA
Margaret C. Weiss
Department of Epidemiology and Biostatistics, School of Public Health, University of Illinois Chicago, Chicago, IL, USA
Jee Young Moon
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA
Krista M. Perreira
Department of Social Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA
Martha L. Daviglus
Institute for Minority Health Research, University of Illinois at Chicago, Chicago, IL, USA
Robert Kaplan
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Kari E. North
Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
Maria Argos
Department of Epidemiology and Biostatistics, School of Public Health, University of Illinois Chicago, Chicago, IL, USA; Department of Environmental Health, School of Public Health, Boston University, Boston, MA, USA
Lindsay Fernández-Rhodes
Department of Biobehavioral Health, Pennsylvania State University, University Park, PA, USA
Tamar Sofer
Cardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA; Corresponding author
The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) is a multicenter, longitudinal cohort study designed to evaluate environmental, lifestyle, and genetic risk factors as they relate to cardiometabolic and other chronic diseases among Hispanic/Latino populations in the United States. Since the study’s inception in 2008, as a result of the study’s robust genetic measures, HCHS/SOL has facilitated major contributions to the field of genetic research. This 10-year retrospective review highlights the major findings for genotype-phenotype relationships and advancements in statistical methods owing to the HCHS/SOL. Furthermore, we discuss the ethical and societal challenges of genetic research, especially among Hispanic/Latino adults in the United States. Continued genetic research, ancillary study expansion, and consortia collaboration through HCHS/SOL will further drive knowledge and advancements in human genetics research.
