Nature Communications (Sep 2021)

Analyses of child cardiometabolic phenotype following assisted reproductive technologies using a pragmatic trial emulation approach

  • Jonathan Yinhao Huang,
  • Shirong Cai,
  • Zhongwei Huang,
  • Mya Thway Tint,
  • Wen Lun Yuan,
  • Izzuddin M. Aris,
  • Keith M. Godfrey,
  • Neerja Karnani,
  • Yung Seng Lee,
  • Jerry Kok Yen Chan,
  • Yap Seng Chong,
  • Johan Gunnar Eriksson,
  • Shiao-Yng Chan

DOI
https://doi.org/10.1038/s41467-021-25899-4
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 16

Abstract

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Huang and colleagues used machine-learning estimators to analyse a broad range of parameters in a prospective cohort consisting ART and spontaneously conceived children. Small differences in stature and growth could not be explained by parental or perinatal environment factors, nor differences in fetal DNA methylation. No strong differences in metabolic parameters were seen.