An HDAC9-MALAT1-BRG1 complex mediates smooth muscle dysfunction in thoracic aortic aneurysm

Christian L. Lino Cardenas; Chase W. Kessinger; Yisha Cheng; Carolyn MacDonald; Thomas MacGillivray; Brian Ghoshhajra; Luai Huleihel; Saifar Nuri; Ashish S. Yeri; Farouc A. Jaffer; Naftali Kaminski; Patrick Ellinor; Neal L. Weintraub; Rajeev Malhotra; Eric M. Isselbacher; Mark E. Lindsay

doi:10.1038/s41467-018-03394-7

Nature Communications (Mar 2018)

An HDAC9-MALAT1-BRG1 complex mediates smooth muscle dysfunction in thoracic aortic aneurysm

Christian L. Lino Cardenas,
Chase W. Kessinger,
Yisha Cheng,
Carolyn MacDonald,
Thomas MacGillivray,
Brian Ghoshhajra,
Luai Huleihel,
Saifar Nuri,
Ashish S. Yeri,
Farouc A. Jaffer,
Naftali Kaminski,
Patrick Ellinor,
Neal L. Weintraub,
Rajeev Malhotra,
Eric M. Isselbacher,
Mark E. Lindsay

Affiliations

Christian L. Lino Cardenas: Thoracic Aortic Center, Massachusetts General Hospital, Harvard Medical School
Chase W. Kessinger: Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School
Yisha Cheng: Thoracic Aortic Center, Massachusetts General Hospital, Harvard Medical School
Carolyn MacDonald: Thoracic Aortic Center, Massachusetts General Hospital, Harvard Medical School
Thomas MacGillivray: Thoracic Aortic Center, Massachusetts General Hospital, Harvard Medical School
Brian Ghoshhajra: Thoracic Aortic Center, Massachusetts General Hospital, Harvard Medical School
Luai Huleihel: McGowan Institute for Regenerative Medicine and Department of Surgery, University of Pittsburgh
Saifar Nuri: Thoracic Aortic Center, Massachusetts General Hospital, Harvard Medical School
Ashish S. Yeri: Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School
Farouc A. Jaffer: Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School
Naftali Kaminski: Pulmonary, Critical Care, and Sleep Medicine, Yale University
Patrick Ellinor: Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School
Neal L. Weintraub: Augusta University/Medical College of Georgia
Rajeev Malhotra: Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School
Eric M. Isselbacher: Thoracic Aortic Center, Massachusetts General Hospital, Harvard Medical School
Mark E. Lindsay: Thoracic Aortic Center, Massachusetts General Hospital, Harvard Medical School

DOI: https://doi.org/10.1038/s41467-018-03394-7
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 14

Abstract

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Vascular smooth muscle cell (VSMC) dysfunction is a common feature of thoracic aortic aneurysms (TAAs). Here, Lino Cardenas and colleagues show that the formation of a HDAC9-MALAT1-BRG1 complex promotes VSMC dysfunction in TAA by epigenetically altering the expression of key components of the cytoskeleton in VSMCs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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