Effect of vitamin C supplement on lead bioaccessibility in contaminated soils using multiple in vitro gastrointestinal assays: Mechanisms and health risks

Naiyi Yin; Zeliang Han; Wenbin Jia; Yaqi Fu; Jingnan Ma; Xiaotong Liu; Xiaolin Cai; Yan Li; Xiaochen Chen; Yanshan Cui

Ecotoxicology and Environmental Safety (Sep 2022)

Effect of vitamin C supplement on lead bioaccessibility in contaminated soils using multiple in vitro gastrointestinal assays: Mechanisms and health risks

Naiyi Yin,
Zeliang Han,
Wenbin Jia,
Yaqi Fu,
Jingnan Ma,
Xiaotong Liu,
Xiaolin Cai,
Yan Li,
Xiaochen Chen,
Yanshan Cui

Affiliations

Naiyi Yin: College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 101408, China; Research Center for Eco-Environment Sciences, Chinese Academy of Sciences, Beijing 100085, China
Zeliang Han: College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 101408, China; Fujian Provincial Engineering Research Center of Rural Waste Recycling Technology, College of Environment and Safety Engineering, Fuzhou University, Fuzhou 350108, China
Wenbin Jia: National Research Center for Geoanalysis, Chinese Academy of Geological Sciences, Beijing 100037, China; Correspondence to: No. 26 baiwanzhuang street, Xicheng District, Beijing 100037, China.
Yaqi Fu: College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 101408, China; Sino-Danish Centre for Education and Research, University of Chinese Academy of Sciences, Beijing 101408, China
Jingnan Ma: College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 101408, China; Sino-Danish Centre for Education and Research, University of Chinese Academy of Sciences, Beijing 101408, China
Xiaotong Liu: College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 101408, China; Research Center for Eco-Environment Sciences, Chinese Academy of Sciences, Beijing 100085, China
Xiaolin Cai: College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 101408, China; Research Center for Eco-Environment Sciences, Chinese Academy of Sciences, Beijing 100085, China
Yan Li: Department of Agricultural, Forest and Food Sciences, University of Turin, Torino 10095, Italy
Xiaochen Chen: Fujian Provincial Engineering Research Center of Rural Waste Recycling Technology, College of Environment and Safety Engineering, Fuzhou University, Fuzhou 350108, China
Yanshan Cui: College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 101408, China; Research Center for Eco-Environment Sciences, Chinese Academy of Sciences, Beijing 100085, China; Correspondence to: College of Resources and Environment, University of Chinese Academy of Sciences, 380 Huaibeizhuang, Huairou District, Beijing 101408, China.

Journal volume & issue: Vol. 243
p. 113968

Abstract

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Effects of vitamin C supplementation on the oral bioaccessibility of lead (Pb) present in contaminated soils were examined using a number of in vitro assays (PBET, SBRC, UBM and IVG). In the presence of vitamin C, an increase in Pb bioaccessibility was observed in the gastric phase by 1.3-fold (30.5%−85.5%) and in the intestinal phase by 3.1-fold (0.9%−58.9%). Lead mobilization was regulated by reductive dissolution of Fe(III) and sequestration of Pb on secondary Fe minerals. Sequential extraction by the Bureau Community of Reference (BCR) provided more evidence that reducible fraction and residual fraction were major contributor of gastric Pb bioaccessibility, as well as reduced fractions in intestinal Pb bioaccessibility. In addition, higher non-carcinogenic risks may occur based on target hazard quotient (THQ ≥ 1). For people exposed to Pb present in soil, the management of vitamin C supplements is of serious concern.

Published in Ecotoxicology and Environmental Safety

ISSN: 0147-6513 (Print); 1090-2414 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Technology: Environmental technology. Sanitary engineering: Environmental pollution; Geography. Anthropology. Recreation: Environmental sciences
Website: https://www.journals.elsevier.com/ecotoxicology-and-environmental-safety

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