Semina: Ciências Agrárias (Feb 2014)

Dissociative anesthetic combination reduces intraocular pressure (IOP) in rabbits

  • Ewaldo de Mattos-Junior ,
  • Olicies da Cunha,
  • Luis Felipe Moraes Barros ,
  • Antonio Humberto Hamad Minervino,
  • Lilian Toshiko Nishimura ,
  • Luis Gustavo Gosuen Gonçalves Dias ,
  • Silvia Renata Gaido Cortopassi

DOI
https://doi.org/10.5433/1679-0359.2014v35n2p905
Journal volume & issue
Vol. 35, no. 2
pp. 905 – 910

Abstract

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The aim of this study was evaluate the effects of three anesthetic combinations, ketamine-midazolam, ketamine-xylazine and tiletamine-zolazepam, on IOP in rabbits. In a experimental, blind, randomized, crossover study, six rabbits were anesthetized with each of 3 treatments in random order. Groups KM (ketamine, 30 mg/kg + midazolam, 1 mg/kg); KX (ketamine, 30 mg/kg + xylazine, 3 mg/kg); and TZ (tiletamine + zolazepam, 20 mg/kg). The drugs were mixed in the same syringe injected intramuscularly (IM) into the quadriceps muscle. IOP was measured before drug administration (baseline) and at 5-minute intervals for 30 minutes. The data were analyzed by a 2-way repeated measures ANOVA followed by Bonferroni test. All groups had significant decreases in IOP compared to baseline (p 0.05). Administration of either ketamine-midazolam, ketamine-xylazine, or tiletamine-zolazepam similarly decrease IOP in rabbits within 30 minutes of injection.

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