Alkyl ammonium hydrogen sulfate immobilized on Fe3O4@SiO2 nanoparticles: a highly efficient catalyst for the multi-component preparation of novel tetrazolo[1,5-a]pyrimidine-6-carboxamide derivatives

Abstract

Abstract In this, a three-component reaction for the preparation of novel tetrazolo[1,5-a]pyrimidine-6-carboxamide derivatives from N,N′-(sulfonylbis(1,4-phenylene))bis(3-oxobutanamide), aldehydes and 1H-tetrazol-5-amine is reported. The application of Fe3O4@SiO2-(PP)(HSO4)2 (A) as a catalyst afforded the desired products (a 1 –a 18 ) in high yields in DMF as solvent as well as under solvent-free conditions.

Keywords

• Tetrazolo[1,5-a]pyrimidine
• Fe3O4@SiO2
• Heterogeneous solid catalyst
• Magnetic separation
• Multi-component reaction