Correlation between mitochondrial dysfunction and the pathogenesis of Parkinson's disease

Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disease. A growing number of studies have shown that mitochondrial dysfunction plays an important role in the pathogenesis of PD. Therefore, this review will mainly discuss the research progress on the correlation between PD and abnormal mitochondrial dynamics, mitochondrial autophapy as well as mitochondrial DNA mutations and mitochondrial complex Ⅰ inhibition.doi：10.3969/j.issn.1672-6731.2014.02.012

Keywords

• Parkinson disease
• Mitochondria
• Autophagy
• DNA, mitochondrial
• Review