Nature Communications (Feb 2021)

Improved protein structure refinement guided by deep learning based accuracy estimation

  • Naozumi Hiranuma,
  • Hahnbeom Park,
  • Minkyung Baek,
  • Ivan Anishchenko,
  • Justas Dauparas,
  • David Baker

DOI
https://doi.org/10.1038/s41467-021-21511-x
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 11

Abstract

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Here the authors present DeepAccNet, a deep learning framework that estimates per-residue accuracy and residue-residue distance signed error in protein models, which are used to guide Rosetta protein structure refinement. Benchmarking suggests an improvement of accuracy prediction and refinement compared to other related state of the art methods.