Biopsy Results Are Not Sufficient to Exclude Breast Implant–associated Anaplastic Large Cell Lymphoma: A Case Mistaken for Disseminated Silicosis

Jonathan Freedman, MD, PhD; Andrew Peredo, MD; Julie Rosser, DO; Nicole Christian, MD; Christodoulos Kaoutzanis, MD

doi:10.1097/GOX.0000000000003153

Plastic and Reconstructive Surgery, Global Open (Sep 2020)

Biopsy Results Are Not Sufficient to Exclude Breast Implant–associated Anaplastic Large Cell Lymphoma: A Case Mistaken for Disseminated Silicosis

Jonathan Freedman, MD, PhD,
Andrew Peredo, MD,
Julie Rosser, DO,
Nicole Christian, MD,
Christodoulos Kaoutzanis, MD

Affiliations

Jonathan Freedman, MD, PhD: From the Divisions of Plastic Surgery and Breast Surgery, Department of Surgery and Department of Pathology, Anschutz Medical Center, University of Colorado, Denver, Colo.
Andrew Peredo, MD: From the Divisions of Plastic Surgery and Breast Surgery, Department of Surgery and Department of Pathology, Anschutz Medical Center, University of Colorado, Denver, Colo.
Julie Rosser, DO: From the Divisions of Plastic Surgery and Breast Surgery, Department of Surgery and Department of Pathology, Anschutz Medical Center, University of Colorado, Denver, Colo.
Nicole Christian, MD: From the Divisions of Plastic Surgery and Breast Surgery, Department of Surgery and Department of Pathology, Anschutz Medical Center, University of Colorado, Denver, Colo.
Christodoulos Kaoutzanis, MD: From the Divisions of Plastic Surgery and Breast Surgery, Department of Surgery and Department of Pathology, Anschutz Medical Center, University of Colorado, Denver, Colo.

DOI: https://doi.org/10.1097/GOX.0000000000003153
Journal volume & issue: Vol. 8, no. 9
p. e3153

Abstract

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Summary. We present a case report of breast implant–associated anaplastic large cell lymphoma (BIA-ALCL) that was mistaken as disseminated silicosis after multiple percutaneous biopsies. The correct diagnosis of BIA-ALCL was confirmed only after a pathologic examination of the capsulectomy specimens. A review of the literature of percutaneous biopsies of ALCL showed a diagnostic yield of only 63%. Although percutaneous biopsies may be facile to obtain and may be diagnostic, in our case, biopsies were not sufficient to exclude the diagnosis of BIA-ALCL.

Published in Plastic and Reconstructive Surgery, Global Open

ISSN: 2169-7574 (Online)
Publisher: Wolters Kluwer
Country of publisher: United States
LCC subjects: Medicine: Surgery
Website: http://www.prsgo.com

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