Metabolic Aging as an Increased Risk for Chronic Obstructive Pulmonary Disease
Claire J. Guo,
Suneeta Godbole,
Wassim W. Labaki,
Katherine A. Pratte,
Jeffrey L. Curtis,
Robert Paine,
Eric Hoffman,
Meilan Han,
Jill Ohar,
Christopher Cooper,
Katerina J. Kechris,
Dawn L. DeMeo,
Russell P. Bowler
Affiliations
Claire J. Guo
Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
Suneeta Godbole
Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
Wassim W. Labaki
Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI 48109, USA
Katherine A. Pratte
Division of Biostatistics and Bioinformatics, National Jewish Health, Denver, CO 80206, USA
Jeffrey L. Curtis
Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI 48109, USA
Robert Paine
Division of Respiratory, Critical Care and Occupational Medicine, University of Utah, Salt Lake City, UT 84132, USA
Eric Hoffman
Department of Radiology, University of Iowa, Iowa City, IA 52242, USA
Meilan Han
Division of Biostatistics and Bioinformatics, National Jewish Health, Denver, CO 80206, USA
Jill Ohar
Section of Pulmonary, Critical Care, Allergy and Immunologic Diseases, Department of Internal Medicine, Wake Forest School of Medicine, Wake Forest University, Winston-Salem, NC 27101, USA
Christopher Cooper
David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
Katerina J. Kechris
Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
Dawn L. DeMeo
Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USA
Russell P. Bowler
Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH 44106, USA
Background/Objectives: Both aging and chronic obstructive pulmonary disease (COPD) are strongly associated with changes in the metabolome; however, it is unknown whether there are common aging/COPD metabolomic signatures and if accelerated aging is associated with COPD. Methods: Plasma from 5704 subjects from the Genetic Epidemiology of COPD study (COPDGene) and 2449 subjects from Subpopulations and intermediate outcome measures in COPD study (SPIROMICS) were profiled using the Metabolon global metabolomics platform (1013 annotated metabolites). Post-bronchodilator spirometry measures of airflow obstruction (forced expiratory volume at one second (FEV1)/forced vital capacity (FVC) 7 years difference between metabolic and actual age) had more severe disease compared with those who had decelerated aging (p < 0.001), with amino acid and glutathione metabolism among pathways overrepresented. Conclusions: These findings suggest a common mechanism between aging and COPD and that COPD is associated with accelerated metabolic aging.
