Cohort profile: investigating SARS-CoV-2 infection and the health and psychosocial impact of the COVID-19 pandemic in the Canadian CHILD Cohort

Rilwan Azeez; Larisa Lotoski; Aimée Dubeau; Natalie Rodriguez; Myrtha E. Reyna; Tyler Freitas; Stephanie Goguen; Maria Medeleanu; Geoffrey L. Winsor; Fiona S. L. Brinkman; Emily E. Cameron; Leslie Roos; Elinor Simons; Theo J. Moraes; Piush J. Mandhane; Stuart E. Turvey; Shelly Bolotin; Kim Wright; Deborah McNeil; David M. Patrick; Jared Bullard; Marc-André Langlois; Corey R. Arnold; Yannick Galipeau; Martin Pelchat; Natasha Doucas; Padmaja Subbarao; Meghan B. Azad

doi:10.4178/epih.e2023091

Epidemiology and Health (Oct 2023)

Cohort profile: investigating SARS-CoV-2 infection and the health and psychosocial impact of the COVID-19 pandemic in the Canadian CHILD Cohort

Rilwan Azeez,
Larisa Lotoski,
Aimée Dubeau,
Natalie Rodriguez,
Myrtha E. Reyna,
Tyler Freitas,
Stephanie Goguen,
Maria Medeleanu,
Geoffrey L. Winsor,
Fiona S. L. Brinkman,
Emily E. Cameron,
Leslie Roos,
Elinor Simons,
Theo J. Moraes,
Piush J. Mandhane,
Stuart E. Turvey,
Shelly Bolotin,
Kim Wright,
Deborah McNeil,
David M. Patrick,
Jared Bullard,
Marc-André Langlois,
Corey R. Arnold,
Yannick Galipeau,
Martin Pelchat,
Natasha Doucas,
Padmaja Subbarao,
Meghan B. Azad

Affiliations

Rilwan Azeez: Department of Immunology, University of Manitoba, Winnipeg, MB, Canada
Larisa Lotoski: Children’s Hospital Research Institute of Manitoba, Winnipeg, MB, Canada
Aimée Dubeau: Division of Respiratory Medicine, Department of Pediatrics and Program in Translational Medicine, SickKids Research Institute, The Hospital for Sick Children, Toronto, ON, Canada
Natalie Rodriguez: Children’s Hospital Research Institute of Manitoba, Winnipeg, MB, Canada
Myrtha E. Reyna: Division of Respiratory Medicine, Department of Pediatrics and Program in Translational Medicine, SickKids Research Institute, The Hospital for Sick Children, Toronto, ON, Canada
Tyler Freitas: Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada
Stephanie Goguen: Children’s Hospital Research Institute of Manitoba, Winnipeg, MB, Canada
Maria Medeleanu: Division of Respiratory Medicine, Department of Pediatrics and Program in Translational Medicine, SickKids Research Institute, The Hospital for Sick Children, Toronto, ON, Canada
Geoffrey L. Winsor: Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada
Fiona S. L. Brinkman: Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada
Emily E. Cameron: Department of Psychology, University of Manitoba, Winnipeg, MB, Canada
Leslie Roos: Children’s Hospital Research Institute of Manitoba, Winnipeg, MB, Canada
Elinor Simons: Children’s Hospital Research Institute of Manitoba, Winnipeg, MB, Canada
Theo J. Moraes: Division of Respiratory Medicine, Department of Pediatrics and Program in Translational Medicine, SickKids Research Institute, The Hospital for Sick Children, Toronto, ON, Canada
Piush J. Mandhane: Department of Pediatrics, University of Alberta, Edmonton, AB, Canada
Stuart E. Turvey: Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada
Shelly Bolotin: Centre for Vaccine Preventable Diseases, University of Toronto; Dalla Lana School of Public Health, University of Toronto; Department of Laboratory Medicine and Pathobiology, University of Toronto; Public Health Ontario, ON, Canada
Kim Wright: Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada
Deborah McNeil: Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada
David M. Patrick: School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada
Jared Bullard: Children’s Hospital Research Institute of Manitoba, Winnipeg, MB, Canada
Marc-André Langlois: Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada
Corey R. Arnold: Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada
Yannick Galipeau: Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada
Martin Pelchat: Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada
Natasha Doucas: CHILD Cohort Study National Parent Engagement Committee
Padmaja Subbarao: Division of Respiratory Medicine, Department of Pediatrics and Program in Translational Medicine, SickKids Research Institute, The Hospital for Sick Children, Toronto, ON, Canada
Meghan B. Azad: Department of Immunology, University of Manitoba, Winnipeg, MB, Canada

DOI: https://doi.org/10.4178/epih.e2023091
Journal volume & issue: Vol. 45

Abstract

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The coronavirus disease 2019 (COVID-19) pandemic has affected all Canadian families, with some impacted differently than others. Our study aims to: (1) determine the prevalence and transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among Canadian families, (2) identify predictors of infection susceptibility and severity of SARS-CoV-2, and (3) identify health and psychosocial impacts of the COVID-19 pandemic. This study builds upon the CHILD Cohort Study, an ongoing multi-ethnic general population prospective cohort consisting of 3,454 Canadian families with children born in Vancouver, Edmonton, Manitoba, and Toronto between 2009 and 2012. During the pandemic, CHILD households were invited to participate in the CHILD COVID-19 Add-On Study involving: (1) brief biweekly surveys about COVID-19 symptoms and testing; (2) quarterly questionnaires assessing COVID-19 exposure and testing, vaccination status, physical and mental health, and pandemic-driven life changes; and (3) in-home biological sampling kits to collect blood and stool. In total, 1,462 households (5,378 participants) consented to the CHILD COVID-19 Add-On Study: 2,803 children (mean±standard deviation [SD], 9.0±2.7 years; range, 0-17 years) and 2,576 adults (mean±SD, 43.0±6.5 years; range, 18-85 years). We will leverage the wealth of pre-pandemic CHILD data to identify risk and resilience factors for susceptibility and severity to the direct and indirect pandemic effects. Our short-term findings will inform key stakeholders and knowledge users to shape current and future pandemic responses. Additionally, this study provides a unique resource to study the long-term impacts of the pandemic as the CHILD Cohort Study continues.

Published in Epidemiology and Health

ISSN: 2092-7193 (Online)
Publisher: Korean Society of Epidemiology
Country of publisher: Korea, Republic of
LCC subjects: Medicine
Website: http://www.e-epih.org/

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