Human Vaccines & Immunotherapeutics (Jun 2017)

Hepatitis B virus vaccination in HIV-infected people: A review

  • François-Xavier Catherine,
  • Lionel Piroth

DOI
https://doi.org/10.1080/21645515.2016.1277844
Journal volume & issue
Vol. 13, no. 6
pp. 1304 – 1313

Abstract

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HBV immunization is highly recommended in people infected with HIV. However, the classical schedule used in the general population has been shown to be insufficient in people living with HIV. This review summarizes the main studies dealing with HBV vaccination in people living with HIV, depending on their baseline status (in particular, never vaccinated, already vaccinated, or with an isolated anti-HBc serological profile). It shows that reinforced 40µg intramuscular HBV vaccination schedules are now frequently recommended, either initially in people never vaccinated, or in the lack of an anamnestic response in other situations. Adjuvants cannot be currently recommended. Anti-HBs titers have to be checked 1 to 2 months following the last vaccine dose, and annually thereafter a booster is necessary if antiHBs titers decrease below 10 mIU/mL. In patients with a CD4 cell count <200/µL, guidelines recommend starting the vaccination regimen as soon as possible after HAART has been started.

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