Nature Communications (Sep 2022)
Taz protects hematopoietic stem cells from an aging-dependent decrease in PU.1 activity
- Kyung Mok Kim,
- Anna Mura-Meszaros,
- Marie Tollot,
- Murali Shyam Krishnan,
- Marco Gründl,
- Laura Neubert,
- Marco Groth,
- Alejo Rodriguez-Fraticelli,
- Arthur Flohr Svendsen,
- Stefano Campaner,
- Nico Andreas,
- Thomas Kamradt,
- Steve Hoffmann,
- Fernando D. Camargo,
- Florian H. Heidel,
- Leonid V. Bystrykh,
- Gerald de Haan,
- Björn von Eyss
Affiliations
- Kyung Mok Kim
- Transcriptional Control of Tissue Homeostasis Lab, Leibniz Institute on Aging, Fritz Lipmann Institute e.V.
- Anna Mura-Meszaros
- Transcriptional Control of Tissue Homeostasis Lab, Leibniz Institute on Aging, Fritz Lipmann Institute e.V.
- Marie Tollot
- Transcriptional Control of Tissue Homeostasis Lab, Leibniz Institute on Aging, Fritz Lipmann Institute e.V.
- Murali Shyam Krishnan
- Transcriptional Control of Tissue Homeostasis Lab, Leibniz Institute on Aging, Fritz Lipmann Institute e.V.
- Marco Gründl
- Transcriptional Control of Tissue Homeostasis Lab, Leibniz Institute on Aging, Fritz Lipmann Institute e.V.
- Laura Neubert
- Transcriptional Control of Tissue Homeostasis Lab, Leibniz Institute on Aging, Fritz Lipmann Institute e.V.
- Marco Groth
- Leibniz Institute on Aging, Fritz Lipmann Institute e.V.
- Alejo Rodriguez-Fraticelli
- Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST)
- Arthur Flohr Svendsen
- Laboratory of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen (UMCG), University of Groningen
- Stefano Campaner
- Center for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia (IIT)
- Nico Andreas
- Institute of Immunology, Jena University Hospital
- Thomas Kamradt
- Institute of Immunology, Jena University Hospital
- Steve Hoffmann
- Leibniz Institute on Aging, Fritz Lipmann Institute e.V.
- Fernando D. Camargo
- Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST)
- Florian H. Heidel
- Leibniz Institute on Aging, Fritz Lipmann Institute e.V.
- Leonid V. Bystrykh
- Laboratory of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen (UMCG), University of Groningen
- Gerald de Haan
- Laboratory of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen (UMCG), University of Groningen
- Björn von Eyss
- Transcriptional Control of Tissue Homeostasis Lab, Leibniz Institute on Aging, Fritz Lipmann Institute e.V.
- DOI
- https://doi.org/10.1038/s41467-022-32970-1
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
Immune system function declines with age, a consequence of defects in hematopoietic stem cells (HSCs). Here the authors show that TAZ buffers age-related loss of PU.1 activity to maintain HSC functionality and identify the surface protein Clca3a1 as a marker of “young-like” HSCs, even in old mice.
