Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata

Eeva Sliz; Jaakko S. Tyrmi; Nilufer Rahmioglu; Krina T. Zondervan; Christian M. Becker; FinnGen; Outi Uimari; Johannes Kettunen

doi:10.1038/s41467-023-35974-7

Nature Communications (Feb 2023)

Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata

Eeva Sliz,
Jaakko S. Tyrmi,
Nilufer Rahmioglu,
Krina T. Zondervan,
Christian M. Becker,
FinnGen,
Outi Uimari,
Johannes Kettunen

Affiliations

Eeva Sliz: Center for Life Course Health Research, Faculty of Medicine, University of Oulu
Jaakko S. Tyrmi: Center for Life Course Health Research, Faculty of Medicine, University of Oulu
Nilufer Rahmioglu: Oxford Endometriosis CaRe Centre, Nuffield Department of Women’s and Reproductive Health, University of Oxford
Krina T. Zondervan: Oxford Endometriosis CaRe Centre, Nuffield Department of Women’s and Reproductive Health, University of Oxford
Christian M. Becker: Oxford Endometriosis CaRe Centre, Nuffield Department of Women’s and Reproductive Health, University of Oxford
FinnGen
Outi Uimari: Department of Obstetrics and Gynecology, Oulu University Hospital
Johannes Kettunen: Center for Life Course Health Research, Faculty of Medicine, University of Oulu

DOI: https://doi.org/10.1038/s41467-023-35974-7
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 14

Abstract

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Many genetic factors that contribute to uterine leiomyomata (UL) - the most common tumours of the female genital tract - remain to be discovered. Here, the authors conduct a UL meta-genome-wide association study, and find loci related to altered muscle tissue biology that are associated with UL.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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