An extended APOBEC3A mutation signature in cancer

Adam Langenbucher; Danae Bowen; Ramin Sakhtemani; Elodie Bournique; Jillian F. Wise; Lee Zou; Ashok S. Bhagwat; Rémi Buisson; Michael S. Lawrence

doi:10.1038/s41467-021-21891-0

Nature Communications (Mar 2021)

An extended APOBEC3A mutation signature in cancer

Adam Langenbucher,
Danae Bowen,
Ramin Sakhtemani,
Elodie Bournique,
Jillian F. Wise,
Lee Zou,
Ashok S. Bhagwat,
Rémi Buisson,
Michael S. Lawrence

Affiliations

Adam Langenbucher: Massachusetts General Hospital Cancer Center, Harvard Medical School
Danae Bowen: Department of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, School of Medicine, University of California Irvine
Ramin Sakhtemani: Massachusetts General Hospital Cancer Center, Harvard Medical School
Elodie Bournique: Department of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, School of Medicine, University of California Irvine
Jillian F. Wise: Massachusetts General Hospital Cancer Center, Harvard Medical School
Lee Zou: Massachusetts General Hospital Cancer Center, Harvard Medical School
Ashok S. Bhagwat: Department of Chemistry, Wayne State University
Rémi Buisson: Department of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, School of Medicine, University of California Irvine
Michael S. Lawrence: Massachusetts General Hospital Cancer Center, Harvard Medical School

DOI: https://doi.org/10.1038/s41467-021-21891-0
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 11

Abstract

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The APOBEC mutation signature contributes to a significant percentage of human cancers. Here the authors via biochemical and computational analyses shed light on how DNA primary sequence and secondary structure jointly influence A3A substrate optimality.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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