Cell Death and Disease (Oct 2023)

Long non-coding RNA NRSN2-AS1 promotes ovarian cancer progression through targeting PTK2/β-catenin pathway

  • Yi-Bo Wu,
  • Shen-Yi Li,
  • Jin-Yan Liu,
  • Jia-Jia Xue,
  • Jin-Fu Xu,
  • Ting Chen,
  • Tian-Yue Cao,
  • Hui Zhou,
  • Tian-Tian Wu,
  • Chun-Lin Dong,
  • Wei-Feng Qian,
  • Long-Wei Qiao,
  • Shun-Yu Hou,
  • Ting Wang,
  • Cong Shen

DOI
https://doi.org/10.1038/s41419-023-06214-z
Journal volume & issue
Vol. 14, no. 10
pp. 1 – 14

Abstract

Read online

Abstract As a common malignant tumor among women, ovarian cancer poses a serious threat to their health. This study demonstrates that long non-coding RNA NRSN2-AS1 is over-expressed in ovarian cancer tissues using patient sample and tissue microarrays. In addition, NRSN2-AS1 is shown to promote ovarian cancer cell proliferation and metastasis both in vitro and in vivo. Mechanistically, NRSN2-AS1 stabilizes protein tyrosine kinase 2 (PTK2) to activate the β-catenin pathway via repressing MG-53-mediated ubiquitinated degradation of PTK2, thereby facilitating ovarian cancer progression. Rescue experiments verify the function of the NRSN2-AS1/PTK2/β-catenin axis and the effects of MG53 on this axis in ovarian cancer cells. In conclusion, this study demonstrates the key role of the NRSN2-AS1/PTK2/β-catenin axis for the first time and explores its potential clinical applications in ovarian cancer.