Communications Biology (Jun 2022)

Four-octyl itaconate improves osteoarthritis by enhancing autophagy in chondrocytes via PI3K/AKT/mTOR signalling pathway inhibition

  • Xuekang Pan,
  • Huajian Shan,
  • Jinyu Bai,
  • Tian Gao,
  • Bao Chen,
  • Zhonghai Shen,
  • Haibin Zhou,
  • Huigen Lu,
  • Lei Sheng,
  • Xiaozhong Zhou

DOI
https://doi.org/10.1038/s42003-022-03592-6
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 10

Abstract

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4-octyl itaconate (OI) attenuates chondrocyte apoptosis and ameliorates cartilage degradation and defection of autophagy induced by IL-1 β via the PI3K/AKT/mTOR pathway. OI improved the autophagy and reduced the inflammation of rat models of osteoarthritis.