Increased generation of Foxp3+ regulatory T cells by manipulating antigen presentation in the thymus

Jiqiang Lin; Lu Yang; Hernandez Moura Silva; Alissa Trzeciak; Yongwon Choi; Susan R. Schwab; Michael L. Dustin; Juan J. Lafaille

doi:10.1038/ncomms10562

Nature Communications (Feb 2016)

Increased generation of Foxp3+ regulatory T cells by manipulating antigen presentation in the thymus

Jiqiang Lin,
Lu Yang,
Hernandez Moura Silva,
Alissa Trzeciak,
Yongwon Choi,
Susan R. Schwab,
Michael L. Dustin,
Juan J. Lafaille

Affiliations

Jiqiang Lin: Molecular Pathogenesis Program, Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
Lu Yang: Molecular Pathogenesis Program, Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
Hernandez Moura Silva: Molecular Pathogenesis Program, Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
Alissa Trzeciak: Molecular Pathogenesis Program, Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
Yongwon Choi: Department of Pathology and Laboratory Medicine, Institute for Immunology, University of Pennsylvania Perelman School of Medicine
Susan R. Schwab: Molecular Pathogenesis Program, Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
Michael L. Dustin: Molecular Pathogenesis Program, Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
Juan J. Lafaille: Molecular Pathogenesis Program, Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA

DOI: https://doi.org/10.1038/ncomms10562
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

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The degree of Treg self-antigen reactivity varies across experimental systems. Here the authors develop a new model of skin autoimmunity and show that the size of tissue-specific Treg pool in the thymus depends on AIRE, the availability of the tissue antigen, and its presentation by dendritic cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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