Inhibition of histone methyltransferase Smyd3 rescues NMDAR and cognitive deficits in a tauopathy mouse model

Jamal B. Williams; Qing Cao; Wei Wang; Young-Ho Lee; Luye Qin; Ping Zhong; Yong Ren; Kaijie Ma; Zhen Yan

doi:10.1038/s41467-022-35749-6

Nature Communications (Jan 2023)

Inhibition of histone methyltransferase Smyd3 rescues NMDAR and cognitive deficits in a tauopathy mouse model

Jamal B. Williams,
Qing Cao,
Wei Wang,
Young-Ho Lee,
Luye Qin,
Ping Zhong,
Yong Ren,
Kaijie Ma,
Zhen Yan

Affiliations

Jamal B. Williams: Department of Physiology and Biophysics, State University of New York at Buffalo, Jacobs School of Medicine and Biomedical Sciences
Qing Cao: Department of Physiology and Biophysics, State University of New York at Buffalo, Jacobs School of Medicine and Biomedical Sciences
Wei Wang: Department of Physiology and Biophysics, State University of New York at Buffalo, Jacobs School of Medicine and Biomedical Sciences
Young-Ho Lee: Department of Physiology and Biophysics, State University of New York at Buffalo, Jacobs School of Medicine and Biomedical Sciences
Luye Qin: Department of Physiology and Biophysics, State University of New York at Buffalo, Jacobs School of Medicine and Biomedical Sciences
Ping Zhong: Department of Physiology and Biophysics, State University of New York at Buffalo, Jacobs School of Medicine and Biomedical Sciences
Yong Ren: Department of Physiology and Biophysics, State University of New York at Buffalo, Jacobs School of Medicine and Biomedical Sciences
Kaijie Ma: Department of Physiology and Biophysics, State University of New York at Buffalo, Jacobs School of Medicine and Biomedical Sciences
Zhen Yan: Department of Physiology and Biophysics, State University of New York at Buffalo, Jacobs School of Medicine and Biomedical Sciences

DOI: https://doi.org/10.1038/s41467-022-35749-6
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 13

Abstract

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The study by Williams et al shows targeting the aberrant histone modifying enzyme Smyd3 rescues NMDAR and cognitive deficits in a mouse model of Alzheimer’s disease. It highlights the potential of epigenetic treatment in neurodegenerative diseases.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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