Hemodynamics of the VenusP Valve System™—an in vitro study

Huang Chen; Huang Chen; Milad Samaee; Michael Tree; Lakshmi Dasi; Ajit Yoganathan

doi:10.3389/fmedt.2024.1376649

Frontiers in Medical Technology (May 2024)

Hemodynamics of the VenusP Valve System™—an in vitro study

Huang Chen,
Huang Chen,
Milad Samaee,
Michael Tree,
Lakshmi Dasi,
Ajit Yoganathan

Affiliations

Huang Chen: Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, United States
Huang Chen: Department of Mechanical Engineering, University of Nevada, Las Vegas, NV, United States
Milad Samaee: Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, United States
Michael Tree: Corvid Technologies LLC, Mooresville, NC, United States
Lakshmi Dasi: Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, United States
Ajit Yoganathan: Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, United States

DOI: https://doi.org/10.3389/fmedt.2024.1376649
Journal volume & issue: Vol. 6

Abstract

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This study aims to evaluate the fluid dynamic characteristics of the VenusP Valve System™ under varying cardiac outputs in vitro. A thorough hemodynamic study of the valve under physiological cardiac conditions was conducted and served as an independent assessment of the performance of the valve. Flow fields downstream of the valve near the pulmonary bifurcation were quantitatively studied by two-dimensional Particle Image Velocimetry (PIV). The obtained flow field was analyzed for potential regions of flow stasis and recirculation, and elevated shear stress and turbulence. High-speed en face imaging capturing the leaflet motion provided data for leaflet kinematic modeling. The experimental conditions for PIV studies were in accordance with ISO 5840-1:2021 standard, and two valves with different lengths and different orientations were studied. Results show good hemodynamics performance for the tested valves according to ISO 5840 standard without significant regions of flow stasis. Observed shear stress values are all well below established hemolysis limits.

Published in Frontiers in Medical Technology

ISSN: 2673-3129 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Medicine (General): Medical technology
Website: https://www.frontiersin.org/journals/medical-technology#

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