Risk factors of dementia in type 2 diabetes mellitus: The Hong Kong diabetes study

Yau-Lam Alex Chau; Ji Won Yoo; Jiandong Zhou; Cosmos LiutaoGuo; Wing Tak Wong; Carlin Chang; Tong Liu; Kamalan Jeevaratnam; Qingpeng Zhang; Gary Tse; Sharen Lee

Aging and Health Research (Sep 2023)

Risk factors of dementia in type 2 diabetes mellitus: The Hong Kong diabetes study

Yau-Lam Alex Chau,
Ji Won Yoo,
Jiandong Zhou,
Cosmos LiutaoGuo,
Wing Tak Wong,
Carlin Chang,
Tong Liu,
Kamalan Jeevaratnam,
Qingpeng Zhang,
Gary Tse,
Sharen Lee

Affiliations

Yau-Lam Alex Chau: Faculty of Pharmaceutical Sciences, The University of British Columbia, British Columbia, Canada; Kent and Medway Medical School, Canterbury, Kent, CT2 7NZ, UK; Diabetes Research Unit, Cardiovascular Analytics Group, PowerHealth Limited, Hong Kong, China
Ji Won Yoo: Faculty of Pharmaceutical Sciences, The University of British Columbia, British Columbia, Canada; Kent and Medway Medical School, Canterbury, Kent, CT2 7NZ, UK; Diabetes Research Unit, Cardiovascular Analytics Group, PowerHealth Limited, Hong Kong, China
Jiandong Zhou: School of Data Science, City University of Hong Kong, Hong Kong, Hong Kong, China; Kent and Medway Medical School, Canterbury, Kent, CT2 7NZ, UK; Diabetes Research Unit, Cardiovascular Analytics Group, PowerHealth Limited, Hong Kong, China
Cosmos LiutaoGuo: Laboratory of Cardiovascular Physiology, Shenzhen Research Institute, Faculty of Medicine, Chinese University of Hong Kong, Shenzhen, China; Kent and Medway Medical School, Canterbury, Kent, CT2 7NZ, UK; Diabetes Research Unit, Cardiovascular Analytics Group, PowerHealth Limited, Hong Kong, China
Wing Tak Wong: School of Life Sciences, Chinese University of Hong Kong, Hong Kong, China; Kent and Medway Medical School, Canterbury, Kent, CT2 7NZ, UK; Diabetes Research Unit, Cardiovascular Analytics Group, PowerHealth Limited, Hong Kong, China
Carlin Chang: Department of Medicine, Queen Mary Hospital, Hong Kong, China; Kent and Medway Medical School, Canterbury, Kent, CT2 7NZ, UK; Diabetes Research Unit, Cardiovascular Analytics Group, PowerHealth Limited, Hong Kong, China
Tong Liu: Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin 300211, China; Kent and Medway Medical School, Canterbury, Kent, CT2 7NZ, UK; Diabetes Research Unit, Cardiovascular Analytics Group, PowerHealth Limited, Hong Kong, China
Kamalan Jeevaratnam: Faculty of Health and Medical Sciences, University of Surrey, GU2 7AL, Guildford, United Kingdom; Kent and Medway Medical School, Canterbury, Kent, CT2 7NZ, UK; Diabetes Research Unit, Cardiovascular Analytics Group, PowerHealth Limited, Hong Kong, China
Qingpeng Zhang: School of Data Science, City University of Hong Kong, Hong Kong, Hong Kong, China
Gary Tse: Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin 300211, China; Faculty of Health and Medical Sciences, University of Surrey, GU2 7AL, Guildford, United Kingdom; School of Nursing and Health Studies, Hong Kong Metropolitan University, Hong Kong, China; Kent and Medway Medical School, Canterbury, Kent, CT2 7NZ, UK; Corresponding author at: Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin 300211, China, School of Nursing and Health Studies, Hong Kong Metropolitan University, Hong Kong, China.
Sharen Lee: Corresponding author at: Diabetes Research Unit, Cardiovascular Analytics Group, China-UK Collaboration, Hong Kong, China.; Laboratory of Cardiovascular Physiology, Shenzhen Research Institute, Faculty of Medicine, Chinese University of Hong Kong, Shenzhen, China; Kent and Medway Medical School, Canterbury, Kent, CT2 7NZ, UK; Diabetes Research Unit, Cardiovascular Analytics Group, PowerHealth Limited, Hong Kong, China

Journal volume & issue: Vol. 3, no. 3
p. 100155

Abstract

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This population-based cohort study investigated the risk factors of incident dementia and vascular dementia in type 2 diabetic patients (≥45 years old) attending the Hong Kong Hospital Authority between 1st January and 31st December 2009.Of the 273,876 patients included,9994 showed incident dementia (median follow-up: 4245 days). Multivariable Cox regression identified older age (HR: 1.09 [95% CI: 1.08–1.10]) and antiplatelet use (HR: 1.36 [1.14–1.62]) as risk factors for incident dementia, and older age (HR: 1.07 [1.06–1.08]), ischemic stroke (HR: 1.47 [1.09–1.98]), fasting blood glucose (HR: 1.10 [1.01–1.20]), antiplatelets (HR: 1.92 [1.51–2.44]), and calcium channel blocker (HR: 1.28 [1.04–1.57]) use as risk factors of incident vascular dementia.

Published in Aging and Health Research

ISSN: 2667-0321 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Special situations and conditions: Geriatrics
Website: https://www.journals.elsevier.com/aging-and-health-research

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