Nature Communications (Aug 2020)
Lung-derived HMGB1 is detrimental for vascular remodeling of metabolically imbalanced arterial macrophages
- Ludovic Boytard,
- Tarik Hadi,
- Michele Silvestro,
- Hengdong Qu,
- Andrew Kumpfbeck,
- Rayan Sleiman,
- Kissinger Hyppolite Fils,
- Dornazsadat Alebrahim,
- Francesco Boccalatte,
- Matthias Kugler,
- Annanina Corsica,
- Bruce E. Gelb,
- Glenn Jacobowitz,
- George Miller,
- Chiara Bellini,
- Jessica Oakes,
- Jean-Sébastien Silvestre,
- Lior Zangi,
- Bhama Ramkhelawon
Affiliations
- Ludovic Boytard
- Division of Vascular Surgery, Department of Surgery, New York University Langone Health
- Tarik Hadi
- Division of Vascular Surgery, Department of Surgery, New York University Langone Health
- Michele Silvestro
- Division of Vascular Surgery, Department of Surgery, New York University Langone Health
- Hengdong Qu
- Division of Vascular Surgery, Department of Surgery, New York University Langone Health
- Andrew Kumpfbeck
- Division of Vascular Surgery, Department of Surgery, New York University Langone Health
- Rayan Sleiman
- Division of Vascular Surgery, Department of Surgery, New York University Langone Health
- Kissinger Hyppolite Fils
- Division of Vascular Surgery, Department of Surgery, New York University Langone Health
- Dornazsadat Alebrahim
- Division of Vascular Surgery, Department of Surgery, New York University Langone Health
- Francesco Boccalatte
- Department of Pathology, New York University Langone Health
- Matthias Kugler
- Department of Cell Biology, New York University Langone Health
- Annanina Corsica
- Division of Vascular Surgery, Department of Surgery, New York University Langone Health
- Bruce E. Gelb
- Transplant Institute, Department of Surgery, New York University Langone Health
- Glenn Jacobowitz
- Division of Vascular Surgery, Department of Surgery, New York University Langone Health
- George Miller
- Department of Cell Biology, New York University Langone Health
- Chiara Bellini
- Department of Bioengineering, Northeastern University
- Jessica Oakes
- Department of Bioengineering, Northeastern University
- Jean-Sébastien Silvestre
- Paris Cardiovascular Research Center, Inserm
- Lior Zangi
- Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai
- Bhama Ramkhelawon
- Division of Vascular Surgery, Department of Surgery, New York University Langone Health
- DOI
- https://doi.org/10.1038/s41467-020-18088-2
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 17
Abstract
Lung damage increases abdominal aortic aneurysm (AAA) incidence, but the mechanism was unclear. Here, the authors show that injured lungs leak HMGB1, increasing RIPK3 expression in arterial macrophages that subsequently alters mitochondrial function, leading to MMP12 expression and AAA development.
