Frontiers in Endocrinology (Jun 2023)

Is increased myocardial triglyceride content associated with early changes in left ventricular function? A 1H-MRS and MRI strain study

  • Astrid Soghomonian,
  • Astrid Soghomonian,
  • Anne Dutour,
  • Anne Dutour,
  • Nadjia Kachenoura,
  • Franck Thuny,
  • Franck Thuny,
  • Adele Lasbleiz,
  • Adele Lasbleiz,
  • Patricia Ancel,
  • Robin Cristofari,
  • Elisabeth Jouve,
  • Umberto Simeoni,
  • Frank Kober,
  • Monique Bernard,
  • Bénédicte Gaborit,
  • Bénédicte Gaborit

DOI
https://doi.org/10.3389/fendo.2023.1181452
Journal volume & issue
Vol. 14

Abstract

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BackgroundType 2 diabetes (T2D) and obesity induce left ventricular (LV) dysfunction. The underlying pathophysiological mechanisms remain unclear, but myocardial triglyceride content (MTGC) could be involved.ObjectivesThis study aimed to determine which clinical and biological factors are associated with increased MTGC and to establish whether MTGC is associated with early changes in LV function.MethodsA retrospective study was conducted using five previous prospective cohorts, leading to 338 subjects studied, including 208 well-phenotyped healthy volunteers and 130 subjects living with T2D and/or obesity. All the subjects underwent proton magnetic resonance spectroscopy and feature tracking cardiac magnetic resonance imaging to measure myocardial strain.ResultsMTGC content increased with age, body mass index (BMI), waist circumference, T2D, obesity, hypertension, and dyslipidemia, but the only independent correlate found in multivariate analysis was BMI (p=0.01; R²=0.20). MTGC was correlated to LV diastolic dysfunction, notably with the global peak early diastolic circumferential strain rate (r=-0.17, p=0.003), the global peak late diastolic circumferential strain rate (r=0.40, p<0.0001) and global peak late diastolic longitudinal strain rate (r=0.24, p<0.0001). MTGC was also correlated to systolic dysfunction via end-systolic volume index (r=-0.34, p<0.0001) and stroke volume index (r=-0.31, p<0.0001), but not with longitudinal strain (r=0.009, p=0.88). Interestingly, the associations between MTGC and strain measures did not persist in multivariate analysis. Furthermore, MTGC was independently associated with LV end-systolic volume index (p=0.01, R²=0.29), LV end-diastolic volume index (p=0.04, R²=0.46), and LV mass (p=0.002, R²=0.58).ConclusionsPredicting MTGC remains a challenge in routine clinical practice, as only BMI independently correlates with increased MTGC. MTGC may play a role in LV dysfunction but does not appear to be involved in the development of subclinical strain abnormalities.

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