mBio
(Apr 2021)
SARS-CoV-2 ORF6 Disrupts Bidirectional Nucleocytoplasmic Transport through Interactions with Rae1 and Nup98
Amin Addetia,
Nicole A. P. Lieberman,
Quynh Phung,
Tien-Ying Hsiang,
Hong Xie,
Pavitra Roychoudhury,
Lasata Shrestha,
Michelle A. Loprieno,
Meei-Li Huang,
Michael Gale,
Keith R. Jerome,
Alexander L. Greninger
Affiliations
Amin Addetia
Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA
Nicole A. P. Lieberman
Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA
Quynh Phung
Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA
Tien-Ying Hsiang
Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, Washington, USA
Hong Xie
Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA
Pavitra Roychoudhury
Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA
Lasata Shrestha
Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA
Michelle A. Loprieno
Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA
Meei-Li Huang
Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA
Michael Gale
Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, Washington, USA
Keith R. Jerome
Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA
Alexander L. Greninger
ORCiD Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA
DOI
https://doi.org/10.1128/mBio.00065-21
Journal volume & issue
Vol. 12,
no. 2
Abstract
Read online
SARS-CoV-2, the causative agent of coronavirus disease 2019 (COVID-19), is an RNA virus with a large genome that encodes multiple accessory proteins. While these accessory proteins are not required for growth in vitro
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