SARS-CoV-2 ORF6 Disrupts Bidirectional Nucleocytoplasmic Transport through Interactions with Rae1 and Nup98

Amin Addetia; Nicole A. P. Lieberman; Quynh Phung; Tien-Ying Hsiang; Hong Xie; Pavitra Roychoudhury; Lasata Shrestha; Michelle A. Loprieno; Meei-Li Huang; Michael Gale; Keith R. Jerome; Alexander L. Greninger

doi:10.1128/mBio.00065-21

mBio (Apr 2021)

SARS-CoV-2 ORF6 Disrupts Bidirectional Nucleocytoplasmic Transport through Interactions with Rae1 and Nup98

Amin Addetia,
Nicole A. P. Lieberman,
Quynh Phung,
Tien-Ying Hsiang,
Hong Xie,
Pavitra Roychoudhury,
Lasata Shrestha,
Michelle A. Loprieno,
Meei-Li Huang,
Michael Gale,
Keith R. Jerome,
Alexander L. Greninger

Affiliations

Amin Addetia: Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA
Nicole A. P. Lieberman: Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA
Quynh Phung: Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA
Tien-Ying Hsiang: Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, Washington, USA
Hong Xie: Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA
Pavitra Roychoudhury: Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA
Lasata Shrestha: Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA
Michelle A. Loprieno: Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA
Meei-Li Huang: Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA
Michael Gale: Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, Washington, USA
Keith R. Jerome: Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA
Alexander L. Greninger: ORCiD; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA

DOI: https://doi.org/10.1128/mBio.00065-21
Journal volume & issue: Vol. 12, no. 2

Abstract

Read online

SARS-CoV-2, the causative agent of coronavirus disease 2019 (COVID-19), is an RNA virus with a large genome that encodes multiple accessory proteins. While these accessory proteins are not required for growth in vitro

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal