Shikonin alleviates asthma phenotypes in mice via an airway epithelial STAT3-dependent mechanism

Zhang Yao; Chen Lizhan; Ouyang Haifeng

doi:10.1515/med-2024-1016

Open Medicine (Oct 2024)

Shikonin alleviates asthma phenotypes in mice via an airway epithelial STAT3-dependent mechanism

Zhang Yao,
Chen Lizhan,
Ouyang Haifeng

Affiliations

Zhang Yao: Department of Respiratory Medicine, Xi’an International Medical Center Hospital, Xi’an, 710101, China
Chen Lizhan: Department of Respiratory Medicine, Xi’an International Medical Center Hospital, Xi’an, 710101, China
Ouyang Haifeng: Department of Respiratory Medicine, Xi’an International Medical Center Hospital, No. 777 Xitai Road, Xi’an, 710101, China

DOI: https://doi.org/10.1515/med-2024-1016
Journal volume & issue: Vol. 19, no. 1
pp. 17 – 35

Abstract

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Asthma is an inflammatory disease where the balance between Th1/Th2 and Th17/Treg plays a crucial role in its pathogenesis. Shikonin is used to treat a variety of autoimmune diseases due to its good anti-inflammatory activity. However, the effect and mechanism of shikonin on asthma remain unknown.

Published in Open Medicine

ISSN: 2391-5463 (Online)
Publisher: De Gruyter
Country of publisher: Poland
LCC subjects: Medicine
Website: https://www.degruyter.com/journal/key/med/html

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Abstract

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