Construction of disease models for cancer and cardiovascular disease induced by dietary inorganic arsenic in China

Abstract

ObjectiveTo construct disease models of dietary inorganic arsenic-induced cancer and cardiovascular disease in China.MethodsThe different health hazard endpoints due to dietary inorganic arsenic should be identified. Based on the epidemiological data of related diseases in the Chinese population， the risk assessment method and counterfactual analysis method were used to calculate the attributable morbidity and mortality of cancer and cardiovascular disease caused by dietary inorganic arsenic exposure. Combined with disability weight and disease course characteristics， a disease model of cancer and cardiovascular disease caused by dietary inorganic arsenic exposure was established.ResultsLifetime persistent dietary exposure to 1.41 μg/（kg∙d） of inorganic arsenic in the population resulted in 0.135%， 0.010% and 0.034% of skin， bladder， and lung cancer incidence with 0.015%， 0.004% and 0.138% of mortality， respectively. The incidence and mortality of cardiovascular diseases caused by 1 μg/（kg∙d） of dietary inorganic arsenic exposure were 0.082% and 0.025%， respectively.ConclusionThe disease model can be used to calculate the burden of disease caused by food contaminants and quantify the health hazards caused by food contaminants.

Keywords

• food contamination
• inorganic arsenic
• disease model