Nature Communications (Oct 2017)
Integrating evolutionary and regulatory information with a multispecies approach implicates genes and pathways in obsessive-compulsive disorder
- Hyun Ji Noh,
- Ruqi Tang,
- Jason Flannick,
- Colm O’Dushlaine,
- Ross Swofford,
- Daniel Howrigan,
- Diane P. Genereux,
- Jeremy Johnson,
- Gerard van Grootheest,
- Edna Grünblatt,
- Erik Andersson,
- Diana R. Djurfeldt,
- Paresh D. Patel,
- Michele Koltookian,
- Christina M. Hultman,
- Michele T. Pato,
- Carlos N. Pato,
- Steven A. Rasmussen,
- Michael A. Jenike,
- Gregory L. Hanna,
- S. Evelyn Stewart,
- James A. Knowles,
- Stephan Ruhrmann,
- Hans-Jörgen Grabe,
- Michael Wagner,
- Christian Rück,
- Carol A. Mathews,
- Susanne Walitza,
- Daniëlle C. Cath,
- Guoping Feng,
- Elinor K. Karlsson,
- Kerstin Lindblad-Toh
Affiliations
- Hyun Ji Noh
- Broad Institute of MIT and Harvard
- Ruqi Tang
- Broad Institute of MIT and Harvard
- Jason Flannick
- Broad Institute of MIT and Harvard
- Colm O’Dushlaine
- Broad Institute of MIT and Harvard
- Ross Swofford
- Broad Institute of MIT and Harvard
- Daniel Howrigan
- Broad Institute of MIT and Harvard
- Diane P. Genereux
- Broad Institute of MIT and Harvard
- Jeremy Johnson
- Broad Institute of MIT and Harvard
- Gerard van Grootheest
- GGZ inGeest and Department of Psychiatry, VU University Medical Center
- Edna Grünblatt
- Department of Child & Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich
- Erik Andersson
- Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet Tomtebodavägen 18A
- Diana R. Djurfeldt
- Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet Tomtebodavägen 18A
- Paresh D. Patel
- Department of Psychiatry, University of Michigan
- Michele Koltookian
- Broad Institute of MIT and Harvard
- Christina M. Hultman
- Department of Medical Epidemiology & Biostatistics, Karolinska Institutet
- Michele T. Pato
- Department of Psychiatry & Behavioral Sciences, USC
- Carlos N. Pato
- Department of Psychiatry & Behavioral Sciences, USC
- Steven A. Rasmussen
- Department of Psychiatry & Human Behavior, Brown Medical School
- Michael A. Jenike
- Department of Psychiatry, Harvard Medical School
- Gregory L. Hanna
- Department of Psychiatry, University of Michigan
- S. Evelyn Stewart
- BC Mental Health & Addictions Research Institute, UBC
- James A. Knowles
- Department of Psychiatry & Behavioral Sciences, USC
- Stephan Ruhrmann
- Department of Psychiatry & Psychotherapy, University of Cologne
- Hans-Jörgen Grabe
- Department of Psychiatry & Psychotherapy, University of Medicine Greifswald
- Michael Wagner
- Department of Psychiatry & Psychotherapy, University of Bonn
- Christian Rück
- Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet Tomtebodavägen 18A
- Carol A. Mathews
- Department of Psychiatry & Genetics Institute, University of Florida
- Susanne Walitza
- Department of Child & Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich
- Daniëlle C. Cath
- Department of Clinical & Health Psychology, Utrecht University
- Guoping Feng
- Department of Brain and Cognitive Sciences, McGovern Institute for Brain Research, Massachusetts Institute of Technology
- Elinor K. Karlsson
- Broad Institute of MIT and Harvard
- Kerstin Lindblad-Toh
- Broad Institute of MIT and Harvard
- DOI
- https://doi.org/10.1038/s41467-017-00831-x
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder with symptoms including intrusive thoughts and time-consuming repetitive behaviors. Here Noh and colleagues identify genes enriched for functional variants associated with increased risk of OCD.
