ALDH1A1 provides a source of meiosis-inducing retinoic acid in mouse fetal ovaries

Josephine Bowles; Chun-Wei Feng; Kim Miles; Jessica Ineson; Cassy Spiller; Peter Koopman

doi:10.1038/ncomms10845

Nature Communications (Feb 2016)

ALDH1A1 provides a source of meiosis-inducing retinoic acid in mouse fetal ovaries

Josephine Bowles,
Chun-Wei Feng,
Kim Miles,
Jessica Ineson,
Cassy Spiller,
Peter Koopman

Affiliations

Josephine Bowles: Institute for Molecular Bioscience, The University of Queensland
Chun-Wei Feng: Institute for Molecular Bioscience, The University of Queensland
Kim Miles: Institute for Molecular Bioscience, The University of Queensland
Jessica Ineson: Institute for Molecular Bioscience, The University of Queensland
Cassy Spiller: Institute for Molecular Bioscience, The University of Queensland
Peter Koopman: Institute for Molecular Bioscience, The University of Queensland

DOI: https://doi.org/10.1038/ncomms10845
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 8

Abstract

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Recent findings have challenged the established concept that retinoic acid (RA) induces foetal germ cells to enter meiosis. Here, Bowles et al. identify the enzyme ALDH1A1 as a source of ovarian RA that may induce meiosis even when other RA-synthetic enzymes are deleted.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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