F1000Research
(Oct 2017)
RNAi targeting Caenorhabditis elegans α-arrestins has small or no effects on lifespan [version 2; referees: 2 approved, 1 approved with reservations]
Sangsoon Park,
Yoonji Jung,
Seon Woo A. An,
Heehwa G. Son,
Wooseon Hwang,
Dongyeop Lee,
Murat Artan,
Hae-Eun H. Park,
Dae-Eun Jeong,
Yujin Lee,
Seung-Jae V. Lee
Affiliations
Sangsoon Park
Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk, 37673, Korea, South
Yoonji Jung
Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk, 37673, Korea, South
Seon Woo A. An
Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk, 37673, Korea, South
Heehwa G. Son
Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk, 37673, Korea, South
Wooseon Hwang
Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk, 37673, Korea, South
Dongyeop Lee
Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk, 37673, Korea, South
Murat Artan
Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk, 37673, Korea, South
Hae-Eun H. Park
Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk, 37673, Korea, South
Dae-Eun Jeong
Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk, 37673, Korea, South
Yujin Lee
Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk, 37673, Korea, South
Seung-Jae V. Lee
School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, Gyeongbuk, 37673, Korea, South
DOI
https://doi.org/10.12688/f1000research.12337.2
Journal volume & issue
Vol. 6
Abstract
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Background: α-arrestins are a family of proteins that are implicated in multiple biological processes, including metabolism and receptor desensitization. Methods: Here, we sought to examine the roles of α-arrestins in the longevity of Caenorhabditis elegans through an RNA interference screen. Results: We found that knocking down each of 24 out of total 29 C. elegans α-arrestins had small or no effects on lifespan. Thus, individual C. elegans α-arrestins may have minor effects on longevity. Conclusions: This study will provide useful information for future research on the functional role of α-arrestins in aging and longevity.
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