F1000Research (Oct 2017)

RNAi targeting Caenorhabditis elegans α-arrestins has small or no effects on lifespan [version 2; referees: 2 approved, 1 approved with reservations]

  • Sangsoon Park,
  • Yoonji Jung,
  • Seon Woo A. An,
  • Heehwa G. Son,
  • Wooseon Hwang,
  • Dongyeop Lee,
  • Murat Artan,
  • Hae-Eun H. Park,
  • Dae-Eun Jeong,
  • Yujin Lee,
  • Seung-Jae V. Lee

DOI
https://doi.org/10.12688/f1000research.12337.2
Journal volume & issue
Vol. 6

Abstract

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Background: α-arrestins are a family of proteins that are implicated in multiple biological processes, including metabolism and receptor desensitization. Methods: Here, we sought to examine the roles of α-arrestins in the longevity of Caenorhabditis elegans through an RNA interference screen. Results: We found that knocking down each of 24 out of total 29 C. elegans α-arrestins had small or no effects on lifespan. Thus, individual C. elegans α-arrestins may have minor effects on longevity. Conclusions: This study will provide useful information for future research on the functional role of α-arrestins in aging and longevity.

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