Clinical Case Reports (Nov 2019)

Assessment by miRNA microarray of an autologous cancer antigen‐pulsed adoptive immune ensemble cell therapy (AC‐ACT) approach; demonstrated induction of anti‐oncogenic and anti‐PD‐L1 miRNAs

  • Masanobu Chinami,
  • Kaoru Iwabuchi,
  • Yoshiteru Muto,
  • Yasuhiko Uchida,
  • Ryu Arita,
  • Rana A. Shuraim,
  • Chaker N. Adra

DOI
https://doi.org/10.1002/ccr3.2343
Journal volume & issue
Vol. 7, no. 11
pp. 2156 – 2164

Abstract

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Abstract A 60‐year‐old woman with stage IV rectal cancer received adoptive cell therapy with autologous cancer antigen (AC‐ACT) causing induction of anti‐oncogenic and anti‐PD‐L1 miRNAs as assessed by miRNA microarray. More than 1 year after AC‐ACT, metastases have been arrested, and the patient reports good quality of life.

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