Nature Communications (May 2020)
Adipocyte Piezo1 mediates obesogenic adipogenesis through the FGF1/FGFR1 signaling pathway in mice
- ShengPeng Wang,
- Shuang Cao,
- Malika Arhatte,
- Dahui Li,
- Yue Shi,
- Sabrina Kurz,
- Jiong Hu,
- Lei Wang,
- Jingchen Shao,
- Ann Atzberger,
- Zheng Wang,
- Changhe Wang,
- Weijin Zang,
- Ingrid Fleming,
- Nina Wettschureck,
- Eric Honoré,
- Stefan Offermanns
Affiliations
- ShengPeng Wang
- Max Planck Institute for Heart and Lung Research, Department of Pharmacology
- Shuang Cao
- Max Planck Institute for Heart and Lung Research, Department of Pharmacology
- Malika Arhatte
- Université Côte d’Azur, Centre National de la Recherche Scientifique, Institut de Pharmacologie Moléculaire et Cellulaire, Labex ICST
- Dahui Li
- The State Key Laboratory of Pharmaceutical Biotechnology, Department of Pharmacology and Pharmacy, The University of Hong Kong
- Yue Shi
- Cardiovascular Research Center, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Key Laboratory of Environment and Genes Related to Diseases
- Sabrina Kurz
- Max Planck Institute for Heart and Lung Research, Department of Pharmacology
- Jiong Hu
- Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University
- Lei Wang
- Max Planck Institute for Heart and Lung Research, Department of Pharmacology
- Jingchen Shao
- Max Planck Institute for Heart and Lung Research, Department of Pharmacology
- Ann Atzberger
- Max Planck Institute for Heart and Lung Research, Flow Cytometry Service Group
- Zheng Wang
- Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi’an Jiaotong University
- Changhe Wang
- Center for Mitochondrial Biology and Medicine, School of Life Science and Technology, Xi’an Jiaotong University
- Weijin Zang
- Department of Pharmacology, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center
- Ingrid Fleming
- Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University
- Nina Wettschureck
- Max Planck Institute for Heart and Lung Research, Department of Pharmacology
- Eric Honoré
- Université Côte d’Azur, Centre National de la Recherche Scientifique, Institut de Pharmacologie Moléculaire et Cellulaire, Labex ICST
- Stefan Offermanns
- Max Planck Institute for Heart and Lung Research, Department of Pharmacology
- DOI
- https://doi.org/10.1038/s41467-020-16026-w
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
Adipose tissue expansion occurs via enlargement of adipocytes as well as the generation of new fat cells, the latter being associated with more favorable metabolic outcomes. Here, the authors show that activation of adipocyte Piezo1 results in release of FGF1 and stimulates the differentiation of adipocyte precursor cells.
