A new method for chemical & radiochemical purification of enriched water used in production [18F] FDG in Iran

Abstract

The 18F radioisotope is produced via the enriched water (H218O) bombardment with a high cyclotron yield. The 18O enrichment value of the water is more than 98% and has been imported from abroad. Hence, only a few percentages of enriched water are used in the first bombardment; the recovered water can be used to produce 18F after removing the chemical and radiochemical impurities. The used water contains organic and inorganic impurities, which should be removed before re-usage. In order to remove organic and inorganic impurities, ultraviolet irradiation and ionic exchange methods were applied in addition to low-temperature condensation in a controlled atmosphere. This study introduced a novel method for purification of used enriched water using chemical and physical methods. The purified enriched water was used for bombardment in cyclotron. Production of 18F radioisotope, and finally the production of 18F-FDG along with the QC test were performed. The qualified results of the 18F-FDG production and its QC tests, confirmed the successful purification of the enriched water.

Keywords

• enriched water
• purification
• 18f-fdg