Insights into SARS-CoV-2: Small-Molecule Hybrids for COVID-19 Treatment

Abstract

The advantages of a treatment modality that combines two or more therapeutic agents with different mechanisms of action encourage the study of hybrid functional compounds for pharmacological applications. Molecular hybridization, resulting from a covalent combination of two or more pharmacophore units, has emerged as a promising approach to overcome several issues and has also been explored for the design of new drugs for COVID-19 treatment. In this review, we presented an overview of small-molecule hybrids from both natural products and synthetic sources reported in the literature to date with potential antiviral anti-SARS-CoV-2 activity.

Keywords

• molecular hybridization
• small molecules
• natural product hybrids
• antiviral activity
• drug design
• COVID-19