Nature Communications (Apr 2021)

A comprehensive characterization of the cell-free transcriptome reveals tissue- and subtype-specific biomarkers for cancer detection

  • Matthew H. Larson,
  • Wenying Pan,
  • Hyunsung John Kim,
  • Ruth E. Mauntz,
  • Sarah M. Stuart,
  • Monica Pimentel,
  • Yiqi Zhou,
  • Per Knudsgaard,
  • Vasiliki Demas,
  • Alexander M. Aravanis,
  • Arash Jamshidi

DOI
https://doi.org/10.1038/s41467-021-22444-1
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 11

Abstract

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Cell-free RNA (cfRNA) is a promising analyte for cancer diagnosis. Here, the authors determine the baseline cell-free transcriptome in the absence of cancer and identify tissue- and subtype-specific cfRNA biomarkers in breast and lung cancer patients.