Nature Communications (Mar 2022)
Deep proteomic profiling unveils arylsulfatase A as a non-alcoholic steatohepatitis inducible hepatokine and regulator of glycemic control
- Magdalene K. Montgomery,
- Jacqueline Bayliss,
- Shuai Nie,
- William De Nardo,
- Stacey N. Keenan,
- Paula M. Miotto,
- Hamzeh Karimkhanloo,
- Cheng Huang,
- Ralf B. Schittenhelm,
- Anthony S. Don,
- Andrew Ryan,
- Nicholas A. Williamson,
- Geraldine J. Ooi,
- Wendy A. Brown,
- Paul R. Burton,
- Benjamin L. Parker,
- Matthew J. Watt
Affiliations
- Magdalene K. Montgomery
- Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine Dentistry and Health Sciences, University of Melbourne
- Jacqueline Bayliss
- Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine Dentistry and Health Sciences, University of Melbourne
- Shuai Nie
- Melbourne Mass Spectrometry and Proteomics Facility, Bio21 Molecular Science & Biotechnology Institute, The University of Melbourne
- William De Nardo
- Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine Dentistry and Health Sciences, University of Melbourne
- Stacey N. Keenan
- Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine Dentistry and Health Sciences, University of Melbourne
- Paula M. Miotto
- Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine Dentistry and Health Sciences, University of Melbourne
- Hamzeh Karimkhanloo
- Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine Dentistry and Health Sciences, University of Melbourne
- Cheng Huang
- Proteomics & Metabolomics Facility, Monash University
- Ralf B. Schittenhelm
- Proteomics & Metabolomics Facility, Monash University
- Anthony S. Don
- School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney
- Andrew Ryan
- TissuPath
- Nicholas A. Williamson
- Melbourne Mass Spectrometry and Proteomics Facility, Bio21 Molecular Science & Biotechnology Institute, The University of Melbourne
- Geraldine J. Ooi
- Centre for Obesity Research and Education, Department of Surgery, Monash University
- Wendy A. Brown
- Centre for Obesity Research and Education, Department of Surgery, Monash University
- Paul R. Burton
- Centre for Obesity Research and Education, Department of Surgery, Monash University
- Benjamin L. Parker
- Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine Dentistry and Health Sciences, University of Melbourne
- Matthew J. Watt
- Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine Dentistry and Health Sciences, University of Melbourne
- DOI
- https://doi.org/10.1038/s41467-022-28889-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
Non-alcoholic steatohepatitis (NASH) and type 2 diabetes are closely linked, but the connecting pathophysiological mechanisms are incompletely understood. Here the authors identify arylsulfatase A as a NASH-induced hepatokine that inhibits hepatic lysophosphatidylcholine and lysophosphatidic acid secretion, and improves muscle insulin action and systemic glucose homeostasis.
