Monanchocidin A From Subarctic Sponges of the Genus Monanchora and Their Promising Selectivity Against Melanoma in vitro

Vedanjali Gogineni; Joonseok Oh; Amanda L. Waters; Michelle Kelly; Robert Stone; Mark T. Hamann

doi:10.3389/fmars.2020.00058

Frontiers in Marine Science (Feb 2020)

Monanchocidin A From Subarctic Sponges of the Genus Monanchora and Their Promising Selectivity Against Melanoma in vitro

Vedanjali Gogineni,
Joonseok Oh,
Amanda L. Waters,
Michelle Kelly,
Robert Stone,
Mark T. Hamann

Affiliations

Vedanjali Gogineni: Department of BioMolecular Sciences, Division of Pharmacognosy, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, MS, United States
Joonseok Oh: Department of BioMolecular Sciences, Division of Pharmacognosy, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, MS, United States
Amanda L. Waters: Department of Chemistry, University of Central Oklahoma, Edmond, OK, United States
Michelle Kelly: Coasts and Oceans, National Institute of Water and Atmospheric Research Ltd., Auckland, New Zealand
Robert Stone: Auke Bay Laboratories, Alaska Fisheries Science Center, NOAA Fisheries, Juneau, AK, United States
Mark T. Hamann: Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, SC, United States

DOI: https://doi.org/10.3389/fmars.2020.00058
Journal volume & issue: Vol. 7

Abstract

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Marine sources have long been known for their potential to produce unique skeletons and various biological activities. Fractionation of the ethanol extracts of an undescribed species of MonanchoraCarter, 1883 and a specimen closely comparable to Monanchora pulchra (Lambe, 1894/1895) (Class Demospongiae, Order Poecilosclerida, Family Crambeidae), yielded a known compound, monanchocidin A. Monanchocidin A, a secondary metabolite, showed very modest antibacterial, antifungal, and antiprotozoal activities with IC50 values ranging between 255.75 and 7288.92 μM. Monanchocidin A also exhibited potent selective activity for the melanoma panel in the NCI cancer cell screening panel.

Published in Frontiers in Marine Science

ISSN: 2296-7745 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Natural history (General): General. Including nature conservation, geographical distribution
Website: https://www.frontiersin.org/journals/marine-science

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