Nature Communications (Jun 2020)
Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer
- Yingsong Lin,
- Masahiro Nakatochi,
- Yasuyuki Hosono,
- Hidemi Ito,
- Yoichiro Kamatani,
- Akihito Inoko,
- Hiromi Sakamoto,
- Fumie Kinoshita,
- Yumiko Kobayashi,
- Hiroshi Ishii,
- Masato Ozaka,
- Takashi Sasaki,
- Masato Matsuyama,
- Naoki Sasahira,
- Manabu Morimoto,
- Satoshi Kobayashi,
- Taito Fukushima,
- Makoto Ueno,
- Shinichi Ohkawa,
- Naoto Egawa,
- Sawako Kuruma,
- Mitsuru Mori,
- Haruhisa Nakao,
- Yasushi Adachi,
- Masumi Okuda,
- Takako Osaki,
- Shigeru Kamiya,
- Chaochen Wang,
- Kazuo Hara,
- Yasuhiro Shimizu,
- Tatsuo Miyamoto,
- Yuko Hayashi,
- Hiromichi Ebi,
- Tomohiro Kohmoto,
- Issei Imoto,
- Yumiko Kasugai,
- Yoshinori Murakami,
- Masato Akiyama,
- Kazuyoshi Ishigaki,
- Koichi Matsuda,
- Makoto Hirata,
- Kazuaki Shimada,
- Takuji Okusaka,
- Takahisa Kawaguchi,
- Meiko Takahashi,
- Yoshiyuki Watanabe,
- Kiyonori Kuriki,
- Aya Kadota,
- Rieko Okada,
- Haruo Mikami,
- Toshiro Takezaki,
- Sadao Suzuki,
- Taiki Yamaji,
- Motoki Iwasaki,
- Norie Sawada,
- Atsushi Goto,
- Kengo Kinoshita,
- Nobuo Fuse,
- Fumiki Katsuoka,
- Atsushi Shimizu,
- Satoshi S. Nishizuka,
- Kozo Tanno,
- Ken Suzuki,
- Yukinori Okada,
- Momoko Horikoshi,
- Toshimasa Yamauchi,
- Takashi Kadowaki,
- Herbert Yu,
- Jun Zhong,
- Laufey T. Amundadottir,
- Yuichiro Doki,
- Hideshi Ishii,
- Hidetoshi Eguchi,
- David Bogumil,
- Christopher A. Haiman,
- Loic Le Marchand,
- Masaki Mori,
- Harvey Risch,
- Veronica W. Setiawan,
- Shoichiro Tsugane,
- Kenji Wakai,
- Teruhiko Yoshida,
- Fumihiko Matsuda,
- Michiaki Kubo,
- Shogo Kikuchi,
- Keitaro Matsuo
Affiliations
- Yingsong Lin
- Department of Public Health, Aichi Medical University School of Medicine
- Masahiro Nakatochi
- Division of Public Health Informatics, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine
- Yasuyuki Hosono
- Division of Molecular Therapeutics, Aichi Cancer Center Research Institute
- Hidemi Ito
- Division of Cancer Information and Control, Aichi Cancer Center Research Institute
- Yoichiro Kamatani
- Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
- Akihito Inoko
- Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute
- Hiromi Sakamoto
- Genetics Division, National Cancer Center Research Institute
- Fumie Kinoshita
- Data Science Division, Data Coordinating Center, Department of Advanced Medicine, Nagoya University Hospital
- Yumiko Kobayashi
- Data Science Division, Data Coordinating Center, Department of Advanced Medicine, Nagoya University Hospital
- Hiroshi Ishii
- Chiba Cancer Center
- Masato Ozaka
- Department of Hepato-biliary-pancreatic Medicine, The Cancer Institute Hospital of Japanese Foundation for Cancer Research
- Takashi Sasaki
- Department of Hepato-biliary-pancreatic Medicine, The Cancer Institute Hospital of Japanese Foundation for Cancer Research
- Masato Matsuyama
- Department of Hepato-biliary-pancreatic Medicine, The Cancer Institute Hospital of Japanese Foundation for Cancer Research
- Naoki Sasahira
- Department of Hepato-biliary-pancreatic Medicine, The Cancer Institute Hospital of Japanese Foundation for Cancer Research
- Manabu Morimoto
- Department of Gastroenterology, Hepatobiliary and Pancreatic Medical Oncology Division, Kanagawa Cancer Center
- Satoshi Kobayashi
- Department of Gastroenterology, Hepatobiliary and Pancreatic Medical Oncology Division, Kanagawa Cancer Center
- Taito Fukushima
- Department of Gastroenterology, Hepatobiliary and Pancreatic Medical Oncology Division, Kanagawa Cancer Center
- Makoto Ueno
- Department of Gastroenterology, Hepatobiliary and Pancreatic Medical Oncology Division, Kanagawa Cancer Center
- Shinichi Ohkawa
- Department of Gastroenterology, Hepatobiliary and Pancreatic Medical Oncology Division, Kanagawa Cancer Center
- Naoto Egawa
- Department of Gastroenterology, Tokyo Metropolitan Hiroo Hospital
- Sawako Kuruma
- Department of Gastroenterology, Tokyo Metropolitan Komagome Hospital
- Mitsuru Mori
- Hokkaido Chitose College of Rehabilitation
- Haruhisa Nakao
- Division of Hepatology and Pancreatology, Aichi Medical University School of Medicine
- Yasushi Adachi
- Sapporo Shirakabadai Hospital
- Masumi Okuda
- Department of Pediatrics, Hyogo College of Medicine
- Takako Osaki
- Department of Infectious Diseases, Kyorin University School of Medicine
- Shigeru Kamiya
- Department of Infectious Diseases, Kyorin University School of Medicine
- Chaochen Wang
- Department of Public Health, Aichi Medical University School of Medicine
- Kazuo Hara
- Department of Gastroenterology, Aichi Cancer Center Hospital
- Yasuhiro Shimizu
- Department of Gastroenterological Surgery, Aichi Cancer Center Hospital
- Tatsuo Miyamoto
- Department of Genetics and Cell Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University
- Yuko Hayashi
- Division of Molecular Therapeutics, Aichi Cancer Center Research Institute
- Hiromichi Ebi
- Division of Molecular Therapeutics, Aichi Cancer Center Research Institute
- Tomohiro Kohmoto
- Department of Human Genetics, Tokushima University Graduate School of Medicine
- Issei Imoto
- Division of Molecular Genetics, Aichi Cancer Center Research Institute
- Yumiko Kasugai
- Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute
- Yoshinori Murakami
- Division of Molecular Pathology, Institute of Medical Science, The University of Tokyo
- Masato Akiyama
- Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
- Kazuyoshi Ishigaki
- Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
- Koichi Matsuda
- Graduate School of Frontier Sciences, The University of Tokyo
- Makoto Hirata
- Division of Molecular Pathology, Institute of Medical Science, The University of Tokyo
- Kazuaki Shimada
- Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital
- Takuji Okusaka
- Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital
- Takahisa Kawaguchi
- Center for Genomic Medicine, Graduate School of Medicine, Kyoto University
- Meiko Takahashi
- Center for Genomic Medicine, Graduate School of Medicine, Kyoto University
- Yoshiyuki Watanabe
- Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine
- Kiyonori Kuriki
- Laboratory of Public Health, School of Food and Nutritional Sciences, University of Shizuoka
- Aya Kadota
- Department of Public Health, Shiga University of Medical Science
- Rieko Okada
- Department of Preventive Medicine, Nagoya University Graduate School of Medicine
- Haruo Mikami
- Cancer Prevention Center, Chiba Cancer Center Research Institute
- Toshiro Takezaki
- Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences
- Sadao Suzuki
- Department of Public Health, Nagoya City University Graduate School of Medical Sciences
- Taiki Yamaji
- Division of Epidemiology, Center for Public Health Sciences, National Cancer Center
- Motoki Iwasaki
- Division of Epidemiology, Center for Public Health Sciences, National Cancer Center
- Norie Sawada
- Division of Epidemiology, Center for Public Health Sciences, National Cancer Center
- Atsushi Goto
- Division of Epidemiology, Center for Public Health Sciences, National Cancer Center
- Kengo Kinoshita
- Tohoku Medical Megabank Organization, Tohoku University
- Nobuo Fuse
- Tohoku Medical Megabank Organization, Tohoku University
- Fumiki Katsuoka
- Tohoku Medical Megabank Organization, Tohoku University
- Atsushi Shimizu
- Iwate Tohoku Medical Megabank Organization, Iwate Medical University
- Satoshi S. Nishizuka
- Iwate Tohoku Medical Megabank Organization, Iwate Medical University
- Kozo Tanno
- Iwate Tohoku Medical Megabank Organization, Iwate Medical University
- Ken Suzuki
- Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
- Yukinori Okada
- Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
- Momoko Horikoshi
- Laboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Centre for Integrative Medical Sciences
- Toshimasa Yamauchi
- Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
- Takashi Kadowaki
- Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
- Herbert Yu
- University of Hawaii Cancer Center
- Jun Zhong
- Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Laufey T. Amundadottir
- Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Yuichiro Doki
- Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University
- Hideshi Ishii
- Department of Medical Data Science, Graduate School of Medicine, Osaka University
- Hidetoshi Eguchi
- Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University
- David Bogumil
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California
- Christopher A. Haiman
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California
- Loic Le Marchand
- University of Hawaii Cancer Center
- Masaki Mori
- Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University
- Harvey Risch
- Department of Chronic Disease Epidemiology, Yale School of Public Health
- Veronica W. Setiawan
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California
- Shoichiro Tsugane
- Center for Public Health Sciences, National Cancer Center
- Kenji Wakai
- Department of Preventive Medicine, Nagoya University Graduate School of Medicine
- Teruhiko Yoshida
- Genetics Division, National Cancer Center Research Institute
- Fumihiko Matsuda
- Center for Genomic Medicine, Graduate School of Medicine, Kyoto University
- Michiaki Kubo
- RIKEN Center for Integrative Medical Sciences
- Shogo Kikuchi
- Department of Public Health, Aichi Medical University School of Medicine
- Keitaro Matsuo
- Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute
- DOI
- https://doi.org/10.1038/s41467-020-16711-w
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
Previous genome-wide association studies have identified risk loci for pancreatic cancer but were centered on individuals of European ancestry. Here the authors identify GP2 gene variants associated with pancreatic cancer susceptibility in populations of East Asian ancestry.
